342808-62-2

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 108-22-5 Isopropenyl acetate 
• 99-90-1 para-bromoacetophenone 
• 108-24-7 acetic anhydride 

Downstream Products

• 915980-51-7 1-(4-bromophenyl)-2-(4-nitrophenyl)ethan-1-one 
• 1182901-92-3 1-(4-bromophenyl)-2-(2-nitrophenyl)ethanone 
• 6127-49-7 2-(4-bromophenyl)indole 
• 99-90-1 para-bromoacetophenone 
• 13541-18-9 1-(4-bromophenyl)-3,3,3-trifluoropropan-1-one 
• 82415-38-1 ethyl 1-hydroxy-2-oxo-1-cyclopentanecarboxylate 
• 1180670-65-8 1-(4'-bromophenyl)-4,4,4-trifluoro-1-butanone 
• 1427206-63-0 C₁₆H₁₆BrNO₃S 
• 51765-77-6 4-(4-bromo-phenyl)-4-oxo-butyronitrile 
• 31377-97-6 1-(4-bromophenyl)-2-tosylethanone 
• 41024-55-9 1-(4-bromophenyl)-2-(phenylsulfonyl)ethanone 
• 54266-09-0 (t-C₄H₉)2SbCH₂COC₆H₄-4-Br 
• 127-19-5 N,N-dimethyl acetamide 

Relevant academic research and scientific papers

Visible-Light-Promoted Synthesis of α-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates

An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CF2H-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of fac-Ir(ppy)3, this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CF2H-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.

Visible light induced C-H monofluoroalkylation to synthesize 1,4-unsaturated compound

We developed a method to synthesize fluorinated 1,4-unsaturated dicarbonyl compounds via photoredox catalyzed radical addition process. Commercially available ethyl bromodifluoroacetate (BrCF2CO2Et) as fluoroalkyl source, the corresponding fluoro-containing dicarbonyl compounds could be obtained in moderate to good yields.

Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of γ-ketonitriles through nitrile alkylation of enol acetates

Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare γ-ketonitriles through the direct C(sp3)-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source.

Salicylic Acid-Catalyzed Arylation of Enol Acetates with Anilines

α-Aryl ketones are both structure moieties commonly found in bioactive compounds and versatile synthetic intermediates for the preparation of drug-like molecules. An operationally simple and scalable protocol has been developed to prepare α-aryl ketones from readily available aromatic amines and enol acetates (or silyl enol ethers). This metal-free methodology features the use of salicylic acid as a convenient catalyst to promote the formation of aryl radicals from in-situ generated aryl diazonium salts, without demanding thermal or photochemical activation. The mild reaction conditions used are compatible with anilines substituted with diverse functionalities. Structural elaboration of some prepared α-aryl ketones was accomplished to illustrate their usefulness as building blocks. (Figure presented.).

Highly efficient Cu(I)-catalyzed trifluoromethylation of aryl(heteroaryl) enol acetates with CF3 radicals derived from CF3SO 2Na and TBHP at room temperature

An efficient method for the Cu(I)-catalyzed synthesis of α-trifluoromethyl ketones via the addition of CF3 to aryl(heteroaryl) enol acetates by using the readily available CF 3SO2Na (Langlois reagent) has been developed. The reaction is experimentally simple and carried out at room temperature, providing good to excellent yields with wide functional group tolerance.

Highly efficient AgBF4-catalyzed synthesis of methyl ketones from terminal alkynes

A silver-catalyzed highly efficient synthesis of a wide range of methyl ketones from terminal alkynes is described. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in moderate to excellent yields, with broad substrate scope, including a variety of aromatic and aliphatic terminal alkynes.