342885-80-7Relevant academic research and scientific papers
A convergent asymmetric synthesis of γ-butenolides
Renard, Marc,Ghosez, Léon A.
, p. 2597 - 2608 (2007/10/03)
The addition of aldehydes to the new enantiomerically pure lithiated sulfoxide-orthoester 13 yielded γ-butenolides of high enantiomeric purities after elimination of phenylsulfinic acid. The cyclocondensation with ketones was less stereoselective. This new asymmetric synthesis of γ-butenolides has been applied to a convergent preparation of the antifungal antibiotic (+)-cerulenin.
