342885-84-1

Upstream product

• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 22693-41-0 2,4,6-Triisopropylthiophenol 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 246862-22-6 3-[(2,4,6-triisopropylphenyl)sulfenyl]propionic acid 
• 246862-24-8 2-(4-methyl-2,6,7-trioxabicyclo[2,2,2]oct-1-yl)ethyl 2,4,6-triisopropylphenyl sulfide 
• 246862-23-7 (3-methyl-3-oxethanyl)methyl 3-[(2,4,6-triisopropylphenyl)sulfenyl]propionate 
• 246862-25-9 (S)-2-(4-methyl-2,6,7-trioxabicyclo[2,2,2]oct-1-yl)ethyl 2,4,6-triisopropylphenyl sulfoxide 
• 246862-28-2 (R)-2-(4-methyl-2,6,7-trioxabicyclo[2,2,2]oct-1-yl)ethyl 2,4,6-triisopropylphenyl sulfoxide 
• 342885-80-7 2-(4-methyl-2,6,7-trioxabicyclo[2,2,2]oct-1-yl)ethyl 2,4,6-triisopropylphenyl sulfoxide 

Relevant academic research and scientific papers

A convergent asymmetric synthesis of γ-butenolides

Addition of aldehydes to the new enantiomerically pure lithiated sulfoxide 4 yielded γ-butenolides of high enantiomeric purities after elimination of phenylsulfinic acid. The reaction with ketones was less stereoselective.

A convergent asymmetric synthesis of γ-butenolides

The addition of aldehydes to the new enantiomerically pure lithiated sulfoxide-orthoester 13 yielded γ-butenolides of high enantiomeric purities after elimination of phenylsulfinic acid. The cyclocondensation with ketones was less stereoselective. This new asymmetric synthesis of γ-butenolides has been applied to a convergent preparation of the antifungal antibiotic (+)-cerulenin.