34297-68-2

Usage

Uses

Used in Pharmaceutical Industry:
3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the creation of new drugs, potentially leading to advancements in medicine.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID serves as an intermediate in the synthesis of agrochemicals. Its involvement in this process is crucial for developing effective products for agricultural applications, such as pesticides and herbicides, which are essential for crop protection and yield enhancement.
Used in Material Development:
3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID is utilized in the development of new materials. Its chemical properties allow it to be integrated into the design and synthesis of innovative materials with potential applications in various industries, including electronics, automotive, and aerospace.
Used in Organic Chemistry Research:
3,5-DIMETHYL-FURAN-2-CARBOXYLIC ACID is also employed in the field of organic chemistry research. It provides researchers with a platform to explore new reactions, mechanisms, and the synthesis of complex organic molecules, thereby contributing to the broader understanding and advancement of organic chemistry.

Upstream product

• 79925-83-0 3,5-dimethyl-furan-2-carbaldehyde 
• 74-88-4 methyl iodide 
• 4412-96-8 3-methylfuran-2-carboxylic acid 
• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 15058-72-7 2,4-dimethylfuran-3-carboxylic acid 
• 3710-43-8 2,4-dimethylfuran 

Relevant academic research and scientific papers

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myocilin. Grp94 has been implicated as a target for several therapeutic areas including glaucoma, cancer metastasis, and multiple myeloma. While 85% identical to other Hsp90 isoforms, the N-terminal ATP-binding site of Grp94 possesses a unique hydrophobic pocket that was used to design isoform-selective inhibitors. Incorporation of a cis-amide bioisostere into the radamide scaffold led to development of the original Grp94-selective inhibitor, BnIm. Structure-activity relationship studies have now been performed on the aryl side chain of BnIm, which resulted in improved analogues that exhibit better potency and selectivity for Grp94. These analogues also manifest superior antimigratory activity in a metastasis model as well as enhanced mutant myocilin degradation in a glaucoma model compared to BnIm.

The Generation and Chemistry of Dianions derived from Furancarboxylic Acids

Methods for the generation of the dianionic species lithium 5-lithiofuran-2-carboxylate (5) and lithium 2-lithiofuran-3-carboxylate (21) from furan-2- and furan-3-carboxylic acids recpectively are described.The reactions of (5) and (21) with a range of electrophiles have been examined; in general these are very efficient with aldehydes and ketones but not as satisfactory with alkyl halides and epoxides.The dianions do not couple with allylic or benzylic halides, nor with nitriles or orthoesters.The generation of lithium-5-lithio-3-methylfuran-2-carboxylate (15) from 3-methyl furan-2-carboxylic acid is also described; the chemistry of (15) is very similar to (5) derived from furan-2-carboxylic acid.