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CAS

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3432-99-3

5,10-Methylenetetrahydrofolate, also known as 5-methyltetrahydrofolate or 5-MTHF, is a biologically active form of the essential B-vitamin, folic acid. It plays a crucial role in various cellular processes, including DNA synthesis, repair, and methylation reactions. 5,10-methylenetetrahydrofolate is particularly important for the proper functioning of the human body, as it is involved in the metabolism of homocysteine and the synthesis of nucleic acids.

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  • L-Glutamic acid,N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-

    Cas No: 3432-99-3

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  • 3432-99-3 Structure

  • Basic information

    1. Product Name: 5,10-methylenetetrahydrofolate
    2. Synonyms: 5,10-METHYLENETETRAHYDROFOLICACID;N-[4-[(3-Amino-1,2,5,6,6a,7,8,9-octahydro-1-oxoimidazo[1,5-f]pteridin)-8-yl]benzoyl]-L-glutamic acid;Folitixorin (Mixture of Diastereomers);ANX-510;(+)-5,10-Methylene-5,6,7,8-tetrahydrofolic Acid;N-[4-(3-AMino-1,2,5,6,6a,7-hexahydro-1-oxoiMidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutaMic Acid;N5,N10-Methyl- enetetrahydrofolic Acid;N5,N10-MethylenetetrahydropteroylglutaMic Acid
    3. CAS NO:3432-99-3
    4. Molecular Formula: C20H23N7O6
    5. Molecular Weight: 457.44
    6. EINECS: N/A
    7. Product Categories: Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
    8. Mol File: 3432-99-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.75g/cm3
    6. Refractive Index: 1.8
    7. Storage Temp.: Hygroscopic, -86°C Freezer, Under inert atmosphere
    8. Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
    9. PKA: 3.47±0.10(Predicted)
    10. Stability: Hygroscopic, Moisture Sensitive, Temperature Sensitive
    11. CAS DataBase Reference: 5,10-methylenetetrahydrofolate(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5,10-methylenetetrahydrofolate(3432-99-3)
    13. EPA Substance Registry System: 5,10-methylenetetrahydrofolate(3432-99-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3432-99-3(Hazardous Substances Data)

3432-99-3 Usage

Uses

Used in Pharmaceutical Industry:
5,10-Methylenetetrahydrofolate is used as a therapeutic agent for the treatment of various health conditions, including anemia, neural tube defects, and certain types of cancer. Its role in DNA synthesis and repair makes it a valuable compound in the development of cancer therapies, as it can help to counteract the negative effects of the disease on cellular processes.
Used in Cancer Treatment:
5,10-Methylenetetrahydrofolate is used as a chemotherapeutic agent in the treatment of cancer. Its ability to support DNA synthesis and repair can help to mitigate the damage caused by cancer cells and promote the recovery of healthy cells. Additionally, it may be used in combination with other cancer treatments to enhance their effectiveness and reduce the risk of side effects.
Used in Prenatal Care:
5,10-Methylenetetrahydrofolate is used as a supplement during pregnancy to prevent neural tube defects in the developing fetus. Its role in the synthesis of nucleic acids and the metabolism of homocysteine makes it an essential nutrient for the proper development of the baby.
Used in Anemia Treatment:
5,10-Methylenetetrahydrofolate is used as a treatment for anemia, particularly in cases where the condition is caused by a deficiency in folic acid. Its ability to support the production of red blood cells and the synthesis of hemoglobin makes it an effective treatment for this condition.
Used in Drug Delivery Systems:
5,10-Methylenetetrahydrofolate can be incorporated into drug delivery systems to improve the efficacy and targeted delivery of various therapeutic agents. Its compatibility with a range of drug carriers, including organic and metallic nanoparticles, makes it a versatile compound for use in the development of novel drug delivery platforms.

Check Digit Verification of cas no

The CAS Registry Mumber 3432-99-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,3 and 2 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3432-99:
(6*3)+(5*4)+(4*3)+(3*2)+(2*9)+(1*9)=83
83 % 10 = 3
So 3432-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1

3432-99-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (6R)-5,10-methylenetetrahydrofolic acid

1.2 Other means of identification

Product number -
Other names 5,10-methylenetetrahydrofolate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3432-99-3 SDS

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