5,10-methylenetetrahydrofolate

Base Information

Chemical Name:5,10-methylenetetrahydrofolate
CAS No.:3432-99-3
Molecular Formula:C₂₀H₂₃N₇O₆
Molecular Weight:457.446
Hs Code.:
Mol file:3432-99-3.mol

Synonyms:Glutamicacid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-,L- (8CI); Imidazo[1,5-f]pteridine, L-glutamic acid deriv.;(+)-5,10-Methylene-5,6,7,8-tetrahydrofolic acid;5,10-Methylene-(6RS)-tetrahydrofolic acid;5,10-Methylene-5,6,7,8-tetrahydrofolic acid; 5,10-Methylenetetrafolate;5,10-Methylenetetrahydrofolic acid; CoFactor; Folic acid,tetrahydro-N5,N10-methylene-; Folitixorin;N5,N10-Methylene-5,6,7,8-tetrahydrofolic acid; N5,N10-Methylenetetrahydrofolicacid; N5,N10-Methylenetetrahydropteroylglutamic acid

Suppliers and Price of 5,10-methylenetetrahydrofolate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Folitixorin(~80%)(MixtureofDiastereomers)
5mg
$ 215.00

American Custom Chemicals Corporation
N-[4-(3-AMINO-1,2,5,6,6A,7-HEXAHYDRO-1-OXOIMIDAZO-[1,5-F]PTERIDIN-8(9H)-YL)BENZOYL]-L-GLUTAMIC ACID 95.00%
50MG
$ 1732.50

American Custom Chemicals Corporation
N-[4-(3-AMINO-1,2,5,6,6A,7-HEXAHYDRO-1-OXOIMIDAZO-[1,5-F]PTERIDIN-8(9H)-YL)BENZOYL]-L-GLUTAMIC ACID 95.00%
5MG
$ 756.25

Total 27 raw suppliers

Chemical Property of 5,10-methylenetetrahydrofolate

Chemical Property:

PKA:3.47±0.10(Predicted)
PSA：194.97000
Density:1.75g/cm³
LogP:0.47940
Storage Temp.:Hygroscopic, -86°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

Folitixorin(~80%)(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5,10-methylenetetrahydrofolate is a stable folate lyophilized compound suitable for use in the treatment of cancer and other therapies.

Technology Process of 5,10-methylenetetrahydrofolate

There total 2 articles about 5,10-methylenetetrahydrofolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135-16-0
tetrahydrofolic acid

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 3432-99-3,7599-43-1,31690-11-6,31690-12-7,64395-42-2
N⁵,N¹⁰-methylene-5,6,7,8-tetrahydrofolate

Guidance literature:: DOI:10.1021/ja01503a043

Reference yield:

: 135-16-0
tetrahydrofolic acid

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 7732-18-5
water

: 3432-99-3,7599-43-1,31690-11-6,31690-12-7,64395-42-2
N⁵,N¹⁰-methylene-5,6,7,8-tetrahydrofolate

Guidance literature:

Reference yield:

: 964-26-1
2'-deoxyuridine-5'-monophosphate

: 3432-99-3,7599-43-1,31690-11-6,31690-12-7,64395-42-2
N⁵,N¹⁰-methylene-5,6,7,8-tetrahydrofolate

: 365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1
thymidine 5'-phosphate

: 5238-86-8
5-(hydroxymethyl)-2′-deoxyuridine-5′-monophosphate

Guidance literature:: With formaldehyd; D-gulose; reduced flavin-dependent thymidylate synthase; glucose oxidase; aq. buffer; Enzymatic reaction;
DOI:10.1021/ja2120822