343233-67-0

Upstream product

• 589-21-9 (4-bromophenyl)hydrazine 
• 100-52-7 benzaldehyde 
• 14580-15-5 2-(4-Bromo-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one 

Downstream Products

• 1527476-68-1 1-(4-bromophenyl)-4-((diphenylphosphoryl)(phenyl)methyl)-3-methyl-1H-pyrazol-5-ol 

Relevant academic research and scientific papers

Organocatalytic Asymmetric Michael/Hemiketalization/Retro-aldol Reaction of α-Nitroketones with Unsaturated Pyrazolones: Synthesis of 3-Acyloxy Pyrazoles

An organocatalytic asymmetric cascade Michael/hemiketalization/retro-aldol reaction between unsaturated pyrazolones and α-nitroketones is described. A bifunctional thiourea catalyst was found to be efficient for this reaction. With 10 mol % of catalyst, high yields as well as excellent enantioselectivities are attained for a variety of 3-acyloxy pyrazoles under mild reaction conditions.