343306-50-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a potential pharmaceutical agent for its biological activity. Piperazine derivatives, to which 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER belongs, are known for their therapeutic potential, and further research may uncover specific applications in medicine.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(3-FORMYL-4-HYDROXYPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is utilized with its tert-butyl ester group acting as a protecting group. This feature allows chemists to carry out reactions without affecting the carboxylic acid functionality, thus facilitating the synthesis of more complex molecules.

InChI:InChI=1/C16H22N2O4/c1-16(2,3)22-15(21)18-8-6-17(7-9-18)13-4-5-14(20)12(10-13)11-19/h4-5,10-11,20H,6-9H2,1-3H3

Upstream product

• 1761-61-1 5-bromosalicyclaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 501085-54-7 5-bromosalicylaldehyde dimethyl acetal 
• 13716-12-6 tri-tert-butyl phosphine 

Relevant academic research and scientific papers

Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity

A series of compounds such as dual serotonin re-uptake inhibitor and 5-HT1A receptor agonist was found to increase central serotonin levels in rat brain to a greater extent than established antidepressants. The dual serotonin (5-HT) re-uptake i

Method for preparing vilazodone intermediate through copper-catalyzed coupling reaction

The invention discloses a method for preparing a vilazodone intermediate through a copper-catalyzed coupling reaction. The method comprises the following steps: step 1, generating 2-hydroxy-5-bromobenzene dimethyl acetal (IV) from 2-hydroxy-5-bromobenzald

Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators

The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms

Method for producing 5-(1-piperazinyl) -benzofuran-2-carboxamide by transition metal-catalyzed amination

1. Process for the preparation of 5-(1-piperazinyl)benzofuran-2-carboxamide in which, as intermediate step, 5-bromosalicylaldehyde or one of its derivatives is reacted in a transition metal-catalysed amination with R2-piperazine, in which R2 is as defined in claim 1.