34331-40-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 

Downstream Products

• 36112-95-5 3-(1-naphthyloxy)propane-1,2-diol 
• 140468-11-7 4-(4-Hexadecyloxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 111841-67-9 2,2-dimethyl-4-[[4-(phenylmethoxy)phenoxy]methyl]-1,3-dioxolane 
• 140468-08-2 4-(3-Dodecyloxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 140468-14-0 4-(3-Benzyloxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 90857-77-5 2,2-dimethyl-4-<(4-tetradecylphenoxy)methyl>-1,3-dioxolane 
• 90857-76-4 2,2-dimethyl-4-<(2-hexadecylphenoxy)methyl>-1,3-dioxolane 
• 140468-07-1 4-(3-Decyloxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 140468-09-3 2,2-Dimethyl-4-(3-tetradecyloxy-phenoxymethyl)-[1,3]dioxolane 
• 140468-10-6 4-(3-Hexadecyloxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 91944-48-8 4-[(4-formylphenoxy)methyl]-2,2-dimethyl-1,3-dioxolane 
• 89812-29-3 racemic di(4-oxyphenyl-2',2'-dimethyl-1',3'-dioxacyclopentyl-4'-methyl)ethanedione-1,2 
• 90857-78-6 2,2-dimethyl-4-<(3-tetradecylphenoxy)methyl>-1,3-dioxolane 
• 111841-37-3 4-(3-Dodecyloxy-2-methyl-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 

Relevant academic research and scientific papers

EFFECT OF CRYSTAL PACKING ON THE SOLID-STATE SPECTRAL PROPERTIES OF VICINAL DIKETONES.

X-ray crystal structures are reported for six substituted benzils: 4,4 prime -dimethoxy(1), 4-ethoxy, 4,4 prime -diethoxy(6), and the meso, racemic, and LL chiral, bis-4,4 prime -(2,2 prime -dimethyl-1,3-dioxacyclopentyl-4-methoxy) benzils. The packing mo

Oligo-glycerol based non-ionic amphiphilic nanocarriers for lipase mediated controlled drug release

A new class of non-ionic amphiphiles is synthesized using a diaryl derivative of diglycerol as a central core and functionalizing it with long alkyl chains (C-12/C-15) and monomethoxy PEG moiety (Mn: 350/550) by following a chemo-enzymatic approach. The aggregation behavior of the amphiphiles in aqueous medium is studied by using dynamic light scattering (DLS) and fluorescence spectroscopy, whereas the size and morphology of the aggregates are studied by transmission electron microscopy (TEM). A hydrophobic dye, Nile red and a hydrophobic drug, nimodipine, are used to demonstrate the nano-carrier capability of these non-ionic amphiphilic systems and the results are compared with amphiphilic analogues obtained from the triaryl derivatives of triglycerol. Thein vitrocontrolled release of the encapsulated dye is successfully carried out in the presence of immobilizedCandida antarcticalipase (Novozym 435). Furthermore, cytotoxicity data is also collected which suggests that the amphiphiles are suitable for biomedical applications.

Metabolism of 2,3-dihydroxypropane-1-sulfonate by marine bacteria

Both enantiomers of the sulfoquinovose breakdown product 2,3-dihydroxypropane-1-sulfonate, an important sulfur metabolite produced by marine algae, were synthesised in a 34S-labelled form and used in feeding experiments with marine bacteria. The labelling was efficiently incorporated into the sulfur-containing antibiotic tropodithietic acid and sulfur volatiles by the algal symbiont Phaeobacter inhibens, but not into sulfur volatiles released by marine bacteria associated with crustaceans. The ecological implications and the relevance of these findings for the global sulfur cycle are discussed.

POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS

Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

BIHETEROCYCLIC COMPOUND

The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X═Y—Z, X—Y═Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

PYRIDINYL BASED APOPTOSIS SIGNAL-REGULATION KINASE INHIBITORS

Apoptosis signal-regulating kinase 1 (ASK1) activation and signaling have been reported to play an important role in a broad range of diseases including neurodegenerative, cardiovascular, inflammatory, autoimmunity and metabolic disorders. Disclosed herein is the synthesis of pyridinyl derived therapeutic agents that function as inhibitors of ASK 1 as well as their pharmaceutical compositions and methods of use.

SUBSTITUTED GUANIDINE DERIVATIVE

The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Small molecule diselenide additives for in vitro oxidative protein folding

The in vitro oxidative folding of disulfide-rich proteins can be challenging. Here we show a new class of small molecule diselenides, which can be easily prepared from inexpensive starting materials, used to enhance oxidative protein folding. These compounds were tested on a model protein, bovine pancreatic trypsin inhibitor. Two of the tested diselenides showed considerable improvement over glutathione and were on par with the previously described selenoglutathione.

Synthesis and cytotoxicity evaluation of aryl triazolic derivatives and their hydroxymethine homologues against B16 melanoma cell line

In this manuscript we describe synthesis and cytotoxicity evaluation of some triazolic derivatives against B16 melanoma cell line. For this purpose, we transformed a set of aromatic aldehydes into terminal alkynes, using Besthmann-Ohira reagent, and we made the corresponding hydroxymethyl homologated alkynes by an acetylene Grignard reagent. These generated two sets of alkynes were then subjected to a copper(I)-catalyzed alkyne-azide cycloaddition reaction (CuAAC) using a solid-supported catalyst (Amberlyst A-21?CuI), with a third set composed of organic azides. Synthesized triazoles were then tested in?vitro against B16 melanoma cell line. Amongst them, compounds a1b1 (R1?=?p-nitrophenyl, R2?=?benzyl), a4b1 (R1?=?naphthyl, R2?=?benzyl) and a4b5 (R1?=?naphthyl, R2?=?(R/S)- dioxolane) showed the best activity against B16 melanoma cells, with IC50of 5.12, 3.89 and 6.60?μM respectively.

Practical synthesis of 1-(2-Nitro-1H-imidazol-1-yl)-3-(tosyloxy) propan-2-yl acetate for the radiosynthesis of [18F]-FMISO

Hypoxia is related with many tumors due to a decreased oxygen condition. Novel synthesis for 1-(2-nitro-1H-imidazol-1-yl)-3-(tosyloxy)propan-2-yl acetate for the radiosynthesis of the [18F]-Flouromisonidazole ([18F]-FMISO), a hypoxia imaging marker used in positron emission tomography, from the readily available starting material is described. In this approach, one-pot two-step syntheses were used for the preparation of the [18F]-FMISO precursors that contain acetyl group. The mild reaction conditions and easy treatments are attractive features in this synthesis. This new synthetic route provides alternative choices for the preparation of hypoxia imaging marker.