343375-66-6Relevant academic research and scientific papers
Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines
Zheng, Yanling,Nie, Xufeng,Long, Yang,Ji, Li,Fu, Haiyan,Zheng, Xueli,Chen, Hua,Li, Ruixiang
supporting information, p. 12384 - 12387 (2019/10/19)
Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst.
Copper-Mediated C-N Coupling of Arylsilanes with Nitrogen Nucleophiles
Morstein, Johannes,Kalkman, Eric D.,Cheng, Chen,Hartwig, John F.
supporting information, p. 5244 - 5247 (2016/11/02)
A method for the oxidative coupling of arylsilanes with nitrogen nucleophiles is reported. This method occurs with a broad range of heptamethyltrisiloxylarenes and nitrogen nucleophiles, proceeds with the arylsilane as limiting reagent, and does not require a fluoride activator with electron-poor arylsilanes. The combination of this method with C-H silylation generates arylamines from unactivated arenes with site selectivity controlled by steric effects. This combination of steps gives direct access to many compounds that cannot be accessed via alternative C-H functionalization methods, including direct C-H amination or the combination of C-H borylation and amination.
Efficient, one-pot, BF3·OEt2-mediated synthesis of substituted N-aryl lactams
Chaturvedi, Devdutt,Chaturvedi, Amit K.,Mishra, Nisha,Mishra, Virendra
, p. 2627 - 2630,4 (2012/12/12)
A quick, efficient, one-pot, BF3·OEt2-mediated synthesis of substituted N-aryl lactams in good to excellent yields by reaction of various substituted arenes with a variety of ω-azido alkanoic acid chlorides at room temperature is reported.
An efficient and novel approach for the synthesis of substituted N-aryl lactams
Chaturvedi, Devdutt,Chaturvedi, Amit K.,Mishra, Nisha,Mishra, Virendra
, p. 9148 - 9151,4 (2012/12/12)
A quick, efficient, one-pot method for the synthesis of substituted N-aryl lactams through the reaction of various kinds of corresponding substituted arenes with a variety of ω-azido alkanoic acid chlorides using a Lewis acid (i.e. EtAlCl2) at room temperature, through the in situ involvement of a Friedel-Crafts reaction followed by intramolecular Schimdt rearrangement was developed, and afforded good to excellent yields.
