34346-01-5 Usage
Description
Poly(D-lactide) (PDLA), a polymer of a stereospecific cyclic di-ester of lactic acid, is used in biomaterial research for the development of devices such as therapeutic drug delivery vessels. Poly(D-lactide) is used for the preparation of microparticles and resorbable polylactide scaffolds.
By poly (D-lactide） made products biological compatibility is good, after the in vivo degradation product by the metabolism out of the body, no harmful and toxic side effects on the human body.
Uses
Different sources of media describe the Uses of 34346-01-5 differently. You can refer to the following data:
1. Poly D-lactide is a bioabsorbable and degradable material. Poly D-lactide can be used in medical fields, such as disposable infusion devices, non-removable surgical sutures; controlled release and slow release packaging agents; tissue engineering scaffolds, bone fixation and bone repair materials, microcapsules for injection, microspheres, implant And animal organs support elastomers and other materials.
At present, it is widely used in the fields of medicine, such as disposable infusion apparatus, free disassembly type suture; drug controlled release, sustained release agent packaging; scaffolds for tissue engineering, bone fixation and bone repairing material, injection with of microcapsules and microspheres, implants and animal organs elastomer material support.
2. Surgical aid (surgical suture material, absorbable).
3. Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.
Check Digit Verification of cas no
The CAS Registry Mumber 34346-01-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,3,4 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 34346-01:
(7*3)+(6*4)+(5*3)+(4*4)+(3*6)+(2*0)+(1*1)=95
95 % 10 = 5
So 34346-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)
34346-01-5Relevant articles and documents
Sustained-release preparation
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, (2008/06/13)
A sustained-release preparation comprising a bioactive substance having an acidic group and a biodegradable polymer having an optionally protected basic group which improves the rate of incorporation of the bioactive substance, suppresses its leakage early after administration, and exhibits constantly suppressed release for an extended period of time.
Method of producing sustained-release preparation
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, (2008/06/13)
A method of producing a sustained-release preparation which includes permitting a water-soluble polypeptide to permeate into a biodegradable matrix in the aqueous solution. The production method of the present invention makes possible the permeation of a water-soluble polypeptide into a biodegradable matrix without bringing the water-soluble polypeptide into contact with an organic solvent. Hence the water-soluble polypeptide is prepared without affecting the water-soluble polypeptide bioactivity and is thus effective for use as a pharmaceutical.
Prolonged release preparation and polymers thereof
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, (2008/06/13)
A polymer for a prolonged release preparation which comprises (A) a polylactic acid and (B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula STR1 wherein R stands for an alkyl group having 2 to 8 carbons, wherein the weight ratio of (A) and (B) is in the range of 10/90 to 90/10. The drug is released at a constant rate from the preparation over the total release period without a large burst at the initial state. Furthermore, the drug release period of the preparation can be freely controlled by varying the blending ratio of (A) and (B).
