34359-77-8

Usage

Uses

Used in Chemical Synthesis:
Trimethyl Orthomethoxyacetate is used as a synthetic intermediate for the preparation of oligoribonucleotides, which are essential in molecular biology and genetic research. Its ability to participate in chemical reactions allows for the creation of complex molecular structures with potential applications in biotechnology and pharmaceuticals.
Used in Organic Chemistry:
Trimethyl Orthomethoxyacetate is used as a reactant in Claisen rearrangements with allylic alcohols. This reaction is a significant method in organic chemistry for the synthesis of various complex molecules, including natural products and pharmaceutical compounds. The use of Trimethyl Orthomethoxyacetate in this context highlights its importance in the development of novel chemical entities with potential applications in various industries.

InChI:InChI=1/C6H14O4/c1-7-5-6(8-2,9-3)10-4/h5H2,1-4H3

Upstream product

• 67-56-1 methanol 
• 1738-36-9 2-methoxyacetonitrile 
• 60-29-7 diethyl ether 

Downstream Products

• 342892-33-5 Methyl 2-Methoxy-3-phenyl-4-pentenoate 
• 54020-52-9 methyl 2-methoxy-4-pentenoate 
• 625-45-6 2-methoxyacetic acid 

Relevant academic research and scientific papers

Preparation method of tetraalkoxy ethane

The invention discloses a preparation method of tetraalkoxy ethane. The structural formula of tetraalkoxy ethane is shown in the description; the preparation method comprises the following steps: taking alkyl alcohol and dichloro ethylene carbonate as the reaction materials for reaction to produce tetraalkoxy ethane, wherein the structural formula of dichloro ethylene carbonate is shown in the description, alkyl alcohol is ROH, R is C1-C4 alkyls, and the reaction temperature is controlled to be 0-100 DEG C. According to the preparation method of tetraalkoxy ethane, the process is simple, the byproduct only comprises carbon dioxide, water and hydrochloric gas, carbon dioxide can escape into the air, and hydrochloric gas can be absorbed by an alkali liquor, so that purification steps of tetraalkoxy ethane are greatly simplified, the content of the obtained tetraalkoxy ethane can reach 90% or above, and the molar yield can reach 85% or above.

1, 2, 4 -TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS

Compounds of formula (I), or a pharmaceutically acceptable salt, solvate, ester or amide thereof, wherein R1 represents [CH2]n-R2; R2 represents H, C1-6 alkyloxy or Het; n represents a numb

SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS

The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).

SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS

The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing, said, inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).

ZnCl2-catalysed cycloadditions between ketene acetals and α,β-unsaturated carbonyl compounds. A simple route to 2,2-dialkoxy-3,4-dihydropyrans

2,2-dialkoxy-3,4-dihydropyrans (3) can be obtained under mild conditions and in good yields from ketene acetals (1) and α,β-unsaturated carbonyl compounds (2) in the presence of ZnCl2.At low temperatures ( -20 deg C) the reaction between 1 and 2 proceeds as a (2 + 2)-cycloaddition, leading to an oxetane (4), which can sometimes be isolated by neutralisation of the Lewis acid.At higher temperatures, however, the oxetanes decompose into the starting compounds, eventually leading to the thermodynamically more stable dihydropyrans.The cycloadditions of tetramethoxyethene (1a) with 2, having no substituents at the β-carbon atom, yield a cyclobutane derivative as the low temperature product; in cycloadditions of α,β-unsaturated esters this is the final product.Cycloadditions of 2-chloroketene acetal (1e) lead in some cases to 2:1 adducts.The deviating behaviour of 1a and 1e is discussed.