3438-15-1

Usage

Uses

Used in Fragrance and Flavor Industry:
2-Chloro-6-methylanisole is used as a fragrance and flavoring agent for its sweet, floral scent. It is incorporated into the production of perfumes, cosmetics, and food products to enhance their aroma and taste.
Used in Pharmaceutical Industry:
As an intermediate in the synthesis of pharmaceuticals, 2-CHLORO-6-METHYLANISOLE plays a crucial role in the development of various medications. Its unique chemical structure allows it to be a key component in the creation of new and innovative drugs.
Used in Agrochemical Industry:
2-Chloro-6-methylanisole is also utilized as an intermediate in the synthesis of agrochemicals. Its application in this industry contributes to the development of effective pesticides and other agricultural products.
It is important to handle 2-Chloro-6-methylanisole with caution and follow proper safety procedures in its handling and use to ensure the safety of both individuals and the environment.

Upstream product

• 67-56-1 methanol 
• 174913-10-1 1-bromo-2-methoxy-3-chlorobenzene 
• 13061-96-6 dihydroxy-methyl-borane 
• 87-64-9 2-chloro-6-methylphenol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 19853-87-3 2-Chlor-4-nitro-6-methylanisol 
• 1044256-94-1 1-(bromomethyl)-3-chloro-2-methoxybenzene 
• 1379325-95-7 2-(3-chloro-2-methoxyphenyl)ethanamine 
• 825654-87-3 2-(3-chloro-2-methoxyphenyl)acetonitrile 
• 19853-88-4 2-Chlor-4-amino-6-methyl-anisol 

Relevant academic research and scientific papers

α,3-Didehydro-5-methyl-6-hydroxytoluene: Matrix isolation of a diradical related to the neocarzinostatin chromophore

UV photolysis of 2,6-dimethylcyclohexa-2,5-dien-1-on-4-ylidene (4), matrix isolated in argon at 10 K, results in the formation of a labile species which is characterized as α,3-didehydro-5-methyl-6-hydroxybenzene (5) by comparison of the experimental IR s

Diphenyl ether derivative, pharmaceutical salts thereof and medicinal use

The invention relates to the field of pharmaceutical chemistry and discloses a compound (I) acting in the aspect of treating diseases related to PD-1/PD-L1 signal channels such as cancer, infectious diseases and autoimmune diseases, pharmaceutical salts a

ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS

The invention provides well-defined aryl fluoroethyl ureas that are useful as selective alpha2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of alpha2 adrenergic receptors.

Two efficient methods for the preparation of 2-chloro-6-methylbenzoic acid

Two efficient methods for the preparation of 2-chloro-6-methylbenzoic acid were developed: one based on nucleophilic aromatic substitution and the other based on carbonylation. In the first approach, 2-chloro-6-fluorobenzaldehyde was converted to its n-butylimine, then treated with 2 equiv of methylmagnesium chloride in THF to give, after hydrolysis, 2-chloro-6-methylbenzaldehyde. Subsequent oxidation of this compound gave the title compound in 85% overall yield. In the second approach, 3-chloro-2-iodotoluene was efficiently carbonylated in methanol to give methyl 2-chloro-6-methylbenzoate, which after hydrolysis afforded the title compound in 94% yield (84% yield after recrystallization). The carbomethoxylation proceeded smoothly even at a high substrate-to-Pd ratio of 10 000. Both methods do not require isolation of intermediates and are suitable for the preparation of kilogram quantities of 2-chloro-6-methylbenzoic acid.