34382-02-0

Usage

Uses

Used in the Food Industry:
2,3,3',4,4'-penta-O-acetylsucrose is used as an intermediate in the synthesis of Sucralose, a high-intensity sweetener that is many times sweeter than sugar. It is used in the food industry to provide sweetness without adding significant calories, making it a popular choice for low-calorie or sugar-free products.
Used in the Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 2,3,3',4,4'-penta-O-acetylsucrose, due to its chemical properties and its role in the synthesis of sweeteners, could potentially be used in the pharmaceutical industry for the development of medications that require a sweetening agent, especially for those that need to be sugar-free or low in calories.
Chemical Properties:
2,3,3',4,4'-penta-O-acetylsucrose is an off-white solid, which indicates its appearance and physical state. This property is important for its handling, storage, and use in various applications, particularly in the synthesis of Sucralose.

Upstream product

• 35867-26-6 2,3,4,3',4'-penta-O-acetyl-6,1',6'-tri-O-tritylsucrose 

Downstream Products

• 81086-98-8 6,6'-di-O-tert-butyldiphenylsilyl-2,3,4,1',3',4'-hexa-O-acetylsucrose 
• 111852-33-6 3,4,3',4'-tetra-O-acetyl-2,1'-anhydro-6,6'-di-O-(tert-butyldiphenylsilyl)-1'-methoxycarbonylmethylsucrose 
• 111852-32-5 1'-aldehydo-6,6'-di-O-(tert-butyldiphenylsilyl)sucrose penta-acetate 
• 111828-99-0 2,3,4,3',4'-penta-O-acetyl-6,6'-di-O-(tert-butyldiphenylsilyl)-1'-deoxy-1'-ethoxycarbonylmethylenesucrose 
• 35867-25-5 2,3,6,3',4'-pentaacetyl sucrose (6-PAS) 
• 64644-62-8 1-chloro-1-deoxy-β-D-fructofuranosyl α-D-glucopyranoside 
• 77453-80-6 2,3,4,3',4'-penta-O-acetyl-6,6'-di-O-benzoyl-1'-O-trimsylsucrose 
• 77453-83-9 2,3,4,3',4'-penta-O-acetyl-6,6'-di-O-benzoyl-1'-chloro-1'-deoxysucrose 
• 77453-81-7 1'-O-trimsylsucrose 
• 86172-10-3 2,3,4,3',4'-penta-O-acetyl-6,6'-di-O-(tert-butyldiphenylsilyl)sucrose 
• 81087-02-7 6,1',6'-tri-(O-tert-butyldiphenylsilyl)sucrose penta-acetate 
• 58510-38-6 2,3,4,3',4'-penta-O-acetyl-6,1',6'-tri-O-trimsylsucrose 

Relevant academic research and scientific papers

Process to Prepare Sucralose

The present invention relates to a process to prepare sucralose. More particularly the said process relates to the production of sucralose, chemically known as, 6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside of formula (1)

AN IMPROVED PROCESS FOR THE PREPARATION OF 2, 3, 6, 3 ', 4 ' - PENTA- O -ACETYLSUCROSE

The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose (6-PAS) (V) from sucrose. Formula (V)

AN IMPROVED PROCESS FOR THE PREPARATION OF 1, 6-DICHLORO-1, 6-DIDE0XY-BETA-D-FRUCT0FURAN0SYL-4-CHL0R0-4-DE0XY-ALPHA-GALACT0PY RANOSIDE

The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose 6-PAS), formula (V) and sucralose, formula (I).

METHOD OF PRODUCING SUCRALOSE

A method of producing sucralose is disclosed. The method of producing sucralose comprises the steps of preparing a compound (6, 1', 6'-tri- 0 -tritylsucrosepenta- acetate) by reacting sucrose, which is a starting material, with a tritylating agent to form a reaction product, and then reacting the reaction product with acetic anhydride (step 1); preparing a compound (2, 3, 4, 3', 4'-penta- 0 -acetylsucrose) by reacting the compound prepared in step 1 with hydrogen chloride gas having the same equivalent amount as the compound (step 2); preparing a compound (2, 3, 6, 3', 4'-penta- 0 -acetylsucrose) by isomerizing the compound prepared in step 2, under a base catalyst (step 3); preparing a compound (4, 1', 6'-trichloro- 4, 1', 6'-trideoxy-2, 3, 6, 3', 4'-penta- 0 -acetyl-galactosucrose) by chlorinating the compound prepared in step 3 (step 4); and preparing 4,1, 6'-trichloro-4, 1', 6'-trideoxygalactosucrose by deacetylating the compound prepared in step 4, and then filtering the deacetylated compound using a cation exchange resin (step 5).

Novel chlorination process for preparing sucralose

A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes for preparing sucralose from sucrose-6-esters are provided.

PROCESS FOR THE PREPARATION OF A GLUCOSE DERIVATIVE

The present invention relates to an improved, safe, commercially viable, cost effective and eco friendly process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (Sucralose). The invention is directed towards the convenient synthesis of 2,3,4,3',4'-penta-O-acetyl sucrose (4-PAS) from 6,1',6'-tri-O-trityl-penta-O-acetyl sucrose ("TRISPA").