35867-26-6

Usage

Uses

Used in Organic Synthesis:
3,4-di-O-acetyl-1,6,6'-tri-O-tribenzylsucrose triacetate is used as a synthetic intermediate for the preparation of various complex organic molecules. Its unique structure allows for selective functionalization and derivatization, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,4-di-O-acetyl-1,6,6'-tri-O-tribenzylsucrose triacetate is used as a key component in the development of novel drug candidates. Its ability to form stable derivatives and its compatibility with a wide range of chemical reactions make it suitable for the creation of new therapeutic agents with improved pharmacological properties.
Used in Material Science:
3,4-di-O-acetyl-1,6,6'-tri-O-tribenzylsucrose triacetate also finds applications in material science, where it can be used to develop new types of polymers and materials with specific properties. Its versatility in chemical modification allows for the fine-tuning of material characteristics, such as solubility, stability, and reactivity, which can be crucial for various high-tech applications.

Upstream product

• 76-83-5 trityl chloride 
• 57-50-1 Sucrose 
• 108-24-7 acetic anhydride 
• 35674-14-7 1,6-di-O-trityl-β-D-fructofuranosyl 6-O-trityl-α-D-glucopyranoside 
• 4217-76-9 methyl α-D-allopyranosyl β-D-fructofuranoside 

Downstream Products

• 75800-74-7 6-O-trityl-α-D-allopyranosyl 1,6-di-O-trityl-β-D-fructofuranoside 
• 34382-02-0 2,3,4,3',4'-penta-O-acetylsucrose 
• 35867-25-5 2,3,6,3',4'-pentaacetyl sucrose (6-PAS) 

Relevant academic research and scientific papers

Process to Prepare Sucralose

The present invention relates to a process to prepare sucralose. More particularly the said process relates to the production of sucralose, chemically known as, 6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside of formula (1)

AN IMPROVED PROCESS FOR THE PREPARATION OF 2, 3, 6, 3 ', 4 ' - PENTA- O -ACETYLSUCROSE

The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose (6-PAS) (V) from sucrose. Formula (V)

AN IMPROVED PROCESS FOR THE PREPARATION OF 1, 6-DICHLORO-1, 6-DIDE0XY-BETA-D-FRUCT0FURAN0SYL-4-CHL0R0-4-DE0XY-ALPHA-GALACT0PY RANOSIDE

The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose 6-PAS), formula (V) and sucralose, formula (I).

METHOD OF PRODUCING SUCRALOSE

A method of producing sucralose is disclosed. The method of producing sucralose comprises the steps of preparing a compound (6, 1', 6'-tri- 0 -tritylsucrosepenta- acetate) by reacting sucrose, which is a starting material, with a tritylating agent to form a reaction product, and then reacting the reaction product with acetic anhydride (step 1); preparing a compound (2, 3, 4, 3', 4'-penta- 0 -acetylsucrose) by reacting the compound prepared in step 1 with hydrogen chloride gas having the same equivalent amount as the compound (step 2); preparing a compound (2, 3, 6, 3', 4'-penta- 0 -acetylsucrose) by isomerizing the compound prepared in step 2, under a base catalyst (step 3); preparing a compound (4, 1', 6'-trichloro- 4, 1', 6'-trideoxy-2, 3, 6, 3', 4'-penta- 0 -acetyl-galactosucrose) by chlorinating the compound prepared in step 3 (step 4); and preparing 4,1, 6'-trichloro-4, 1', 6'-trideoxygalactosucrose by deacetylating the compound prepared in step 4, and then filtering the deacetylated compound using a cation exchange resin (step 5).

Novel chlorination process for preparing sucralose

A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes for preparing sucralose from sucrose-6-esters are provided.

PROCESS FOR THE PREPARATION OF A GLUCOSE DERIVATIVE

The present invention relates to an improved, safe, commercially viable, cost effective and eco friendly process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (Sucralose). The invention is directed towards the convenient synthesis of 2,3,4,3',4'-penta-O-acetyl sucrose (4-PAS) from 6,1',6'-tri-O-trityl-penta-O-acetyl sucrose ("TRISPA").

α-D-ALLOPYRANOSYL β-D-FRUCTOFURANOSIDE (allo-SUCROSE) AND ITS DERIVATIVES

Reduction of 3-ketosucrose (1) with sodium borohydride gave mainly α-D-allopyranosyl β-D-fructofuranoside (2), characterised as its octabenzoate.Using sodium borodeuteride, allo-sucrose (5) and sucrose (6) were obtained in the ratio 12:1.The mixture was fractionated on Dowex-50 X8 resin , and the derivatives were isolated as their octa-acetates.Inspection of the (13)C-n.m.r. spectra of 5 and 6 enabled the C-3 signals to be assigned, allo-Sucrose (2) was more readily obtained by oxidation of sucrose with dimethyl sulphoxide-acetic anhydride followed by reduction with sodium borohydride and fractionation on Dowex-50 X8 resin.Tritylation of 2 followed by acetylation gave, after chromatography, the 6,1',6'-tritrityl ether (9, 10percent), the 6,6'-ditrityl ether (10, 26percent), and a mixture of monotrityl ethers (20percent).Hydrogenolysis of 9 and 10 gave the penta-acetate and hexa-acetate, respectively, with no detectable migration of AcO-4.Treatment of 2 with sulphuryl chloride at -50 degC gave the 6,6'-dichloride.