35867-25-5

Usage

Chemical Properties

2,3,6,3',4'-penta-O-acetylsucrose is White Solid

Uses

2,3,4,3',4'-Penta-O-acetylsucrose is used in the synthesis of Sucralose sweetener.

Upstream product

• 126-14-7 sucrose octaacetate 
• 34382-02-0 2,3,4,3',4'-penta-O-acetylsucrose 
• 35867-26-6 2,3,4,3',4'-penta-O-acetyl-6,1',6'-tri-O-tritylsucrose 
• 35520-98-0 3,4,-di-O-acetyl-β-D-fructofuranosyl 2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside 

Downstream Products

• 55832-20-7 2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside 
• 61854-83-9 1',6'-dichloro-1',6'-dideoxysucrose 
• 309261-86-7 3,4,6-tri-O-acetyl-1-O-tert-butyldiphenylsilyl-β-D-fructofuranosyl-2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside 
• 56038-15-4 Acetic acid (2R,3R,4S,5S)-4-acetoxy-5-((2R,3R,4S,5R,6R)-3,4-diacetoxy-6-acetoxymethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-5-hydroxymethyl-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 56720-37-7 2,3,4,6,3',4'-Hexa-O-acetyl-1',6'-di-O-tosylsucrose 
• 131143-07-2 2,3,6,3',4'-Penta-O-acetyl-1',6'-di-O-tosylsucrose 

Relevant academic research and scientific papers

Process to Prepare Sucralose

The present invention relates to a process to prepare sucralose. More particularly the said process relates to the production of sucralose, chemically known as, 6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside of formula (1)

AN IMPROVED PROCESS FOR THE PREPARATION OF 2, 3, 6, 3 ', 4 ' - PENTA- O -ACETYLSUCROSE

The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose (6-PAS) (V) from sucrose. Formula (V)

AN IMPROVED PROCESS FOR THE PREPARATION OF 1, 6-DICHLORO-1, 6-DIDE0XY-BETA-D-FRUCT0FURAN0SYL-4-CHL0R0-4-DE0XY-ALPHA-GALACT0PY RANOSIDE

The present invention relates to an improved process for the preparation of 2, 3, 6, 3', 4'- Penta-O-acetylsucrose 6-PAS), formula (V) and sucralose, formula (I).

Novel chlorination process for preparing sucralose

A process for preparing a sucralose-6-ester, a key intermediate to sucralose. The process contains (a) creating a heterogeneous mixture comprising a first phase comprising a sucrose-6-ester and a second phase comprising a chlorinating reagent; and (b) reacting the sucrose-6-ester with the chlorinating reagent, to prepare a sucralose-6-ester. In addition, processes for preparing sucralose from sucrose-6-esters are provided.

METHOD OF PRODUCING SUCRALOSE

A method of producing sucralose is disclosed. The method of producing sucralose comprises the steps of preparing a compound (6, 1', 6'-tri- 0 -tritylsucrosepenta- acetate) by reacting sucrose, which is a starting material, with a tritylating agent to form a reaction product, and then reacting the reaction product with acetic anhydride (step 1); preparing a compound (2, 3, 4, 3', 4'-penta- 0 -acetylsucrose) by reacting the compound prepared in step 1 with hydrogen chloride gas having the same equivalent amount as the compound (step 2); preparing a compound (2, 3, 6, 3', 4'-penta- 0 -acetylsucrose) by isomerizing the compound prepared in step 2, under a base catalyst (step 3); preparing a compound (4, 1', 6'-trichloro- 4, 1', 6'-trideoxy-2, 3, 6, 3', 4'-penta- 0 -acetyl-galactosucrose) by chlorinating the compound prepared in step 3 (step 4); and preparing 4,1, 6'-trichloro-4, 1', 6'-trideoxygalactosucrose by deacetylating the compound prepared in step 4, and then filtering the deacetylated compound using a cation exchange resin (step 5).

PROCESS FOR THE PREPARATION OF A GLUCOSE DERIVATIVE

The present invention relates to an improved, safe, commercially viable, cost effective and eco friendly process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (Sucralose). The invention is directed towards the convenient synthesis of 2,3,4,3',4'-penta-O-acetyl sucrose (4-PAS) from 6,1',6'-tri-O-trityl-penta-O-acetyl sucrose ("TRISPA").

Regioselective Enzymatic Deacetylation of Sucrose Octaacetate in Organic Solvents.

The first examples of deacetylation of sucrose octaacetate using proteases and lipases in organic solvents are reported.The regiochemistry of the product sucrose hepta-, hexa- and pentaacetates was established by perdeuteroacetylation and 1H-NMR.Preparation of key intermediates in the commerical synthesis of the high intensity sweetener, sucralose was achieved.