34386-60-2Relevant articles and documents
Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action
Kleijn, Laurens H. J.,Oppedijk, Sabine F.,T Hart, Peter,Van Harten, Roel M.,Martin-Visscher, Leah A.,Kemmink, Johan,Breukink, Eefjan,Martin, Nathaniel I.
, p. 3569 - 3574 (2016)
Laspartomycin C is a lipopeptide antibiotic with activity against a range of Gram-positive bacteria including drug-resistant pathogens. We report the first total synthesis of laspartomycin C as well as a series of structural variants. Laspartomycin C was found to specifically bind undecaprenyl phosphate (C55-P) and inhibit formation of the bacterial cell wall precursor lipid II. While several clinically used antibiotics target the lipid II pathway, there are no approved drugs that act on its C55-P precursor.
A mild and versatile method for the synthesis of alkyl ethers from methoxymethyl ethers and application to the preparation of sterically crowded ethers
Minamitsuji, Yutaka,Kawaguchi, Atsuhisa,Kubo, Ozora,Ueyama, Yoshifumi,Maegawa, Tomohiro,Fujioka, Hiromichi
supporting information; experimental part, p. 1861 - 1866 (2012/09/22)
A mild and divergent route for the synthesis of alkyl ethers from methoxymethyl (MOM) and methoxyethyl (ME) ether derivatives via pyridinium-type salt intermediates has been developed. The addition of organocuprates to the salts afforded the corresponding alkyl ethers, including highly crowded ones, in high yields even in the presence of acid- or base-sensitive functional groups. Copyright
The chemistry of alkylstrontium halide analogues, Part 2: Barbier-type dialkylation of esters with alkyl halides
Miyoshi, Norikazu,Matsuo, Tsuyoshi,Wada, Makoto
, p. 4253 - 4255 (2007/10/03)
The chemistry of an alkylstrontium halide analogue was examined. In the presence of metallic strontium, the Barbier-type alkylation of esters with alkyl iodides proceeded smoothly at room temperature, under argon, to afford the corresponding dialkylated alcohols in good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.