343866-81-9

Basic information

• Product Name: 3-benzoyl-4-(t-butylamino)-3-penten-2-one
• CAS NO: 343866-81-9
• Molecular Weight: 259.348
• Mol File: 343866-81-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzoyl-4-(t-butylamino)-3-penten-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzoyl-4-(t-butylamino)-3-penten-2-one(343866-81-9)
• EPA Substance Registry System: 3-benzoyl-4-(t-butylamino)-3-penten-2-one(343866-81-9)

Safety Data

• Hazardous Substances Data: 343866-81-9(Hazardous Substances Data)

Upstream product

• 59487-13-7 N-tert-butyl-4-amino-3-penten-2-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 30859-61-1 4-acetyl-3-methyl-1,5-diphenylpyrazole 
• 1157-37-5 (3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)phenylmethanone 
• 31539-68-1 4-benzoyl-1,3,5-trimethylpyrazole 
• 77435-41-7 4-acetyl-1,3-dimethyl-5-phenylpyrazole 
• 73225-12-4 3-methyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole 
• 3729-90-6 3-methyl-1,5-diphenyl-1H-pyrazole 
• 108086-92-6 3-benzoyl-4-(methylamino)-3-penten-2-one 

Relevant articles and documents

Study of the reactivity of α-acylenaminoketones. Synthesis of pyrazoles

The reactions of 4-(methylamino)-3-penten-2-one with diazoketones yielded the α-acylenaminoketones 1-3 in good yields. Preparation of the α-acylenaminoketone 4 was carried out by treatment of 4-(t-butylamino)-3-penten-2-one with benzoyl chloride being followed by reaction of transamination with methylamine. The reactions were carried out in five different solvents and were submitted to gas chromatography/mass spectrometry analysis, with the goal of obtaining substituted pyrazoles and determining which of the carbonyls would preferentially be attacked by the nucleophile. The reactions of compounds 1-4 with hydrazine reagents led to the formation of the pyrazoles 5-7a-q. Small amounts of 4-methylamino-2-pentenones 10a-q, amides 11a-q and pyrazoles 12a-q were also obtained in these reactions. The unexpected formation of pyrazoles 15d,h,q was detected when methanol and N,N-dimethylformamide were used as solvents in the reactions of α-acylenaminoketone 4 with hydrazine reagents.