343879-73-2Relevant academic research and scientific papers
Dichloromethane as a Reactant in the Synthesis of 1,2,3,4-Tetrahydropyrimidine Derivatives
Martens, Thierry,Souquet, Florence
, p. 1671 - 1683 (2007/10/02)
5-p-methoxyphenyl-1,2-dithiole-3-thione (Sulfarlem) reacts with primary amines in dichloromethane to give in good yield 1,3-dialkyl-6-methoxyphenyl-1,2,3,4-tetrahydropyrimidine-5-carbothioamides.In this reaction dichloromethane serves as a C-1 unit donor yielding, in the presence of elemental sulphur, 1,3,5-trisubstituted 1,3,5-triazanes and 3,5-disubstituted 1,3,5-thiadiazanes.These Mannich-type compounds react with enamine intermediates to give the title products.
