34392-84-2

Basic information

• Product Name: N~2~,N~2~-diethyl-2,5-pyridinediamine(SALTDATA: FREE)
• Synonyms: N~2~,N~2~-diethyl-2,5-pyridinediamine(SALTDATA: FREE)
• CAS NO: 34392-84-2
• Molecular Formula: C₉H₁₅N₃
• Molecular Weight: 165.2355
• Mol File: 34392-84-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 309.807°C at 760 mmHg
• Flash Point: 141.167°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.584
• PKA: 7.81±0.10(Predicted)
• CAS DataBase Reference: N~2~,N~2~-diethyl-2,5-pyridinediamine(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: N~2~,N~2~-diethyl-2,5-pyridinediamine(SALTDATA: FREE)(34392-84-2)
• EPA Substance Registry System: N~2~,N~2~-diethyl-2,5-pyridinediamine(SALTDATA: FREE)(34392-84-2)

Safety Data

• Hazardous Substances Data: 34392-84-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H15N3/c1-3-12(4-2)9-6-5-8(10)7-11-9/h5-7H,3-4,10H2,1-2H3

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 1509928-37-3 5-azido-2-(N,N-diethylamino)pyridine 
• 506-59-2 N,N-dimethylammonium chloride 
• 3979-51-9 Isopropanol-d1 
• 67-56-1 methanol 
• 20168-70-1 u202fN,N-diethyl-5-nitropyridin-2-amine 

Downstream Products

• 681138-33-0 4'-O-demethyl-4β-[4''-(2''-N,N-diethyl)-pyridylamino]-desoxypodophyllotoxin 

Relevant articles and documents

Design, synthesis and biological evaluation N2-(2-alkyoxy-6-aliphatic aminopyridin-3-yl)-2,4-diaminepyrimidine derivatives bearing acylamino or DBTD ‘head’ as potential ALK inhibitors

Aiming to develop promising ALK inhibitors, two series of N2-(2-alkyoxy-6-aliphatic aminopyridin-3-yl)-2,4-diaminepyrimidine derivatives (22a-x and 23a-d) were designed according to scaffold hopping and bioisosterism principles. All compounds were efficiently synthesized by concise reactions and anti-proliferative activities on ALK-addicted H2228, Karpas299 cells and EGFR-expressive A549 cell were evaluated by MTT assay. Several compounds exhibited potential cytotoxic activities with IC50 values below 0.10 μM. Five compounds (22g, 22h, 22l, 22s and 23a) were selected for further enzymatic determination, resulting in the discovery of 22l against ALK and ALKL1196M with IC50 values of 2.1 nM and 3.8 nM. Particularly, western blot and cell apoptosis assays identified 22l as a promising ALK inhibitor, which was capable of obviously inhibiting cellular ALK activity and inducing cell apoptosis. Eventually, molecular docking modes of 22l with ALK confirmed structural basis in accordance with the SARs analysis.

Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors

In a discovery effort to find safe and effective DGAT-1 inhibitors, we have identified 2-phenyloxazole 4-carboxamide 1 as a conformationally constrained analog of a hydrazide hit, which was previously identified from high-throughput screening. Further optimization of this series has led to chemically more stable 2-phenyloxazole-based DGAT-1 inhibitor 25 with improved solubility, cell-based activity, and pharmacokinetic properties. Compound 25 also demonstrated in vivo efficacy in a diet-induced obesity (DIO) rat model.

Diacylglycerol acyltransferase inhibitors

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.