N2,N2-Diethylpyridine-2,5-diamine

Base Information

• Chemical Name: N2,N2-Diethylpyridine-2,5-diamine
• CAS No.: 34392-84-2
• Molecular Formula: C9H15N3
• Molecular Weight: 165.238
• Hs Code.: 2933399090
• European Community (EC) Number: 888-052-8
• ChEMBL ID: CHEMBL4529057
• DSSTox Substance ID: DTXSID60472628
• Wikidata: Q82301635
• Mol file: 34392-84-2.mol

Synonyms:34392-84-2;N2,N2-Diethylpyridine-2,5-diamine;N2,N2-Diethyl-2,5-pyridinediamine;2-N,2-N-diethylpyridine-2,5-diamine;N~2~,N~2~-DIETHYL-2,5-PYRIDINEDIAMINE;N2,N2-diethyl-pyridine-2,5-diamine;5-amino-2-diethylaminopyridine;SCHEMBL2793295;CHEMBL4529057;DTXSID60472628;OBNDQWYYQMAJDN-UHFFFAOYSA-N;MFCD09046037;AKOS000130032;SB54841;EN300-41876;Z239126196

Chemical Property of N2,N2-Diethylpyridine-2,5-diamine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 309.807°C at 760 mmHg
• PKA: 7.81±0.10(Predicted)
• Flash Point: 141.167°C
• PSA: 42.15000
• Density: 1.06g/cm³
• LogP: 2.09120
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 165.126597491
• Heavy Atom Count: 12
• Complexity: 123

Purity/Quality:

98%min ^*data from raw suppliers

N2,N2-Diethyl-2,5-pyridinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C1=NC=C(C=C1)N

Technology Process of N2,N2-Diethylpyridine-2,5-diamine

There total 6 articles about N2,N2-Diethylpyridine-2,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

u202fN,N-diethyl-5-nitropyridin-2-amine (20168-70-1) → 2-diethylamino-5-amino pyridine (34392-84-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h;

Reference yield: 48.0%

methanol (67-56-1) + 5-azido-2-(N,N-diethylamino)pyridine (1509928-37-3) → u202fN2,N2-diethyl-6-methoxypyridine-2,5-diamine (1095033-53-6) + 2-diethylamino-5-amino pyridine (34392-84-2)

Guidance literature:

at 20 - 25 ℃; for 2.5h; Inert atmosphere; Flash photolysis;

DOI:10.1021/ja405637b

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 2-diethylamino-5-amino pyridine (34392-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 4 h / 30 °C

2: tin(II) chloride dihdyrate / methanol / 48 h / 45 °C

With tin(II) chloride dihdyrate; In methanol; ethanol;

DOI:10.1021/ja405637b

upstream raw materials:

u202fN,N-diethyl-5-nitropyridin-2-amine

methanol

5-azido-2-(N,N-diethylamino)pyridine

Isopropanol-d1

Downstream raw materials:

4'-O-demethyl-4β-[4''-(2''-N,N-diethyl)-pyridylamino]-desoxypodophyllotoxin