3441-00-7

Basic information

• Product Name: 5-(3-METHYLPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(3-METHYLPHENYL)-1H-TETRAZOLE;5-(m-Tolyl)-1H-tetrazole;5-(3-methylphenyl)-2H-tetrazole
• CAS NO: 3441-00-7
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Product Categories: Heterocycles
• Mol File: 3441-00-7.mol
• Article Data: 47

Chemical Properties

• Melting Point: 143-146°C
• Boiling Point: 350.3°Cat760mmHg
• Flash Point: 168.8°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 4.44E-05mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• BRN: 131205
• CAS DataBase Reference: 5-(3-METHYLPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-METHYLPHENYL)-1H-TETRAZOLE(3441-00-7)
• EPA Substance Registry System: 5-(3-METHYLPHENYL)-1H-TETRAZOLE(3441-00-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 3441-00-7(Hazardous Substances Data)

Usage

General Description

5-(3-Methylphenyl)-1H-tetrazole is a chemical compound that belongs to the category of organic compounds known as aryl tetrazoles. It is characterized by a tetrazole ring that carries an aryl group, in this case, 3-methylphenyl. Tetrazoles are a class of five-membered heterocyclic compounds that consist of four nitrogen atoms and one carbon atom. They are highly reactive and versatile, being used in a variety of chemical syntheses and transformations. The 3-methylphenyl group of 5-(3-methylphenyl)-1H-tetrazole lends additional chemical properties to the compound such as hydrophobicity, aromaticity, and the potential for further chemical modifications. It may be used in the synthetic preparation of pharmaceuticals and other chemical products.

InChI:InChI=1/C8H8N4/c1-6-3-2-4-7(5-6)8-9-11-12-10-8/h2-5H,1H3,(H,9,10,11,12)

Upstream product

• 620-22-4 3-Methylbenzonitrile 
• 17846-68-3 azido tributyltin (IV) 
• 17933-03-8 m-tolylboronic acid 
• 79344-08-4 1-benzyl-5-bromo-1H-tetrazole 
• 620-23-5 m-tolyl aldehyde 
• 52707-50-3 3-methylbenzaldehyde oxime 
• 591-17-3 meta-bromotoluene 

Relevant articles and documents

1-Disulfo-[2,2-bipyridine]-1,1-diium chloride ionic liquid as an efficient catalyst for the green synthesis of 5-substituted 1H-tetrazoles

A simple, green and efficient method has been developed for the synthesis of 5-substituted 1H-tetrazole derivatives through [2+3] cycloaddition reaction in good to excellent yields between various benzonitriles and sodium azide. For this purpose, 1-disulfo-[2,2-bipyridine]-1,1-diium chloride ([BiPy](HSO3)2Cl2) system as an ionic liquid catalyst have been extended for the construction of these valuable products. This procedure has significant advantages, including using ethylene glycol as a green solvent. The other advantages of this method are inexpensive and ease the preparation of the catalyst, mild reaction conditions, green reaction medium, easy workup, short reaction time, and simple experimental process.

The mineral alum: an effective and low-cost heterogeneous catalyst for the successful synthesis of 5-substituted-1H-tetrazoles

A simple, efficient, and green procedure for the synthesis of 5-substituted-1H-tetrazoles via [3 + 2] cycloaddition reaction of nitriles with sodium azide is described. The reaction was catalyzed by natural and mesoporous alum nanoparticles (NPs) in DMSO

Methionine-Coated Fe3O4 Nanoparticles: An Efficient and Reusable Nanomagnetic Catalyst for the Synthesis of 5-Substituted 1H-Tetrazoles

Abstract: Methionine-coated Fe3O4 nanoparticles, a magnetically reusable and environmentally friendly heterogeneous catalyst, was synthesized. The new catalyst was characterized by FT-IR spectra, XRD, SEM, and EDX analysis and was us