1874-39-1

Basic information

• Product Name: 2-(3-methylphenyl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 1,3,4-oxadiazole, 2-(3-methylphenyl)-5-phenyl-; 2-Phenyl-5-m-tolyl-[1,3,4]oxadiazole
• CAS NO: 1874-39-1
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.2686
• Mol File: 1874-39-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 400.1°C at 760 mmHg
• Flash Point: 194.1°C
• Density: 1.149g/cm³
• Vapor Pressure: 3.02E-06mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-(3-methylphenyl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylphenyl)-5-phenyl-1,3,4-oxadiazole(1874-39-1)
• EPA Substance Registry System: 2-(3-methylphenyl)-5-phenyl-1,3,4-oxadiazole(1874-39-1)

Safety Data

• Hazardous Substances Data: 1874-39-1(Hazardous Substances Data)

Usage

Compound class

oxadiazole

Core structure

1,3,4-oxadiazole

Substituents

phenyl and methylphenyl

Potential applications

pharmaceuticals, agrochemicals, and materials with specific properties

Role in synthesis

valuable building block for the synthesis of various organic compounds with diverse functionalities

Further research needed

to explore its full potential and possible applications in different fields.

Upstream product

• 6935-65-5 3,N,N-trimethylbenzamide 
• 32818-95-4 N-benzylidene-N'-tert-butylhydrazine 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 99-04-7 m-Toluic acid 
• 13050-47-0 3-methylbenzoyl hydrazine 
• 611-73-4 Benzoylformic acid 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 625-95-6 3-Iodotoluene 
• 100-47-0 benzonitrile 
• 67-66-3 chloroform 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 119072-55-8 tert-butylisonitrile 
• 613-94-5 benzoic acid hydrazide 
• 620-23-5 m-tolyl aldehyde 

Relevant articles and documents

UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

Photocatalyzed facile synthesis of 2,5-diaryl 1,3,4-oxadiazoles with polyaniline-?g-C3N4-TiO2 composite under visible light

PANI (polyaniline)-g-C3N4-TiO2 composite was prepared and found to be efficient for the synthesis of 2,5-diaryl 1,3,4-oxadiazoles under visible light. This reaction involved decarboxylation and cyclization from α-keto acids with acylhydrazines, and a broad scope of substrates were tolerated to provide the desired products in moderate to good yields. Control experiments indicated that a radical pathway was involved in the present photocatalytic reaction and a synergistic effect may exist in the ternary composite. Moreover, this semiconductor photocatalyst could be readily recovered and showed good reusability with only slight decrease in the catalytic activity after six consecutive runs.

Ligand-free Cu(ii)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N′-diacylhydrazines and 1,3,4-oxadiazoles

A Cu(ii)-mediated synthesis of N,N′-diacylhydrazines and 1,3,4-oxadiazoles from aldehyde hydrazones has been developed. This is the first time that the synthesis of N,N′-diacylhydrazines and 1,3,4-oxadiazoles using N,N-dimethylamides as the acylation reagent and O2 in air as the oxidation reagent is reported. These reactions offered several advantages including simple workups, ligand-free inexpensive metal salts as mediators, high yields, and wide scope of substrates.