34418-48-9Relevant academic research and scientific papers
Synthesis method of 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice
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Paragraph 0035-0036, (2020/04/06)
The invention discloses a synthesis method of a 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice. The synthesis method comprises the steps: taking nicotinamide as a starting material, and carrying out a reaction with P2S5 to obtain thionicotinamide; carrying out a cyclization reaction on thionicotinamide and ethyl 2-chloroacetoacetate to obtain 2-pyridyl-4-methylthiazole-5-ethyl formate; hydrolyzing 2-pyridyl-4-methylthiazole-5-ethyl formate to obtain 2-pyridyl-4-methylthiazole-5-formic acid; and under the action of an acid catalyst, synthesizing the 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice at high efficiency. The spice has good antibacterial performance, can resist various bacteria, can be used for animal feeding attraction and cosmetics at the same time, can be used for animal feeding attraction, can increase the palatability and feed intake of poultry, and more importantly can improve the immunity of poultry and reduce the incidence rate; when the spice is used for cosmetics, an antiseptic and antibacterial agent and essence do not need to be added additionally while skin care is conducted, discomfort of sensitive skin is reduced, and the spice has good application prospects.
