344245-65-4

Usage

Cyclopropane derivative

Yes
It is derived from cyclopropane, a three-carbon ring structure.

Class

Cyclopropanecarboxylic acids
It belongs to a group of organic compounds that contain a cyclopropane ring with a carboxylic acid functional group.

Use

Intermediate in synthesis
It is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Antimicrobial properties

Potential
The compound has shown potential as an antimicrobial agent, which could be useful in fighting bacterial infections.

Antifungal properties

Potential
It also has potential antifungal properties, which could be beneficial in treating fungal infections.

Disease treatment potential

Yes
Due to its unique chemical properties, it has been studied for its potential use in the treatment of certain diseases and conditions.

Chemical structure

1,2-Cyclopropanedicarboxylic acid with a 3,4-dichlorophenyl group attached
The compound consists of a cyclopropane ring with two carboxylic acid groups (-COOH) at the 1 and 2 positions, and a 3,4-dichlorophenyl group attached to the cyclopropane ring.

Applications

Pharmaceutical and agrochemical industries
It is primarily used in the development and production of pharmaceuticals and agrochemicals due to its versatile chemical properties.

Research focus

Exploring its potential in disease treatment and antimicrobial/antifungal applications
Ongoing research is focused on understanding the compound's effectiveness in treating diseases and its potential as an antimicrobial and antifungal agent.

Upstream product

• 6725-44-6 methyl 2-(3,4-dichlorophenyl)acetate 
• 163339-71-7 α-bromo-3,4-dichlorophenylacetic acid methyl ester 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 345212-00-2 diethyl cis-1-(3,4-dichlorophenyl)-1,2-cyclopropanedicarboxylate 
• 877397-17-6 1-(3,4-dichlorophenyl)-1,2-cyclopropane-dicarboxylic acid dimethyl ester 

Downstream Products

• 66504-44-7 (±)-1-(3,4 dichlorophenyl)-3-azabicyclo[3.1.0]-hexane-2,4-dione 
• 923567-78-6 1-(3,4-dichloro-phenyl)-3-oxa-bicyclo[3.1.0]hexane-2,4-dione 
• 410074-74-7 (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride 
• 410074-74-7 Amitifadine hydrochloride 
• 86215-36-3 (+/-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0.]hexane hydrochloride 

Relevant academic research and scientific papers

USE OF AMITIFADINE, (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN METHODS AND COMPOSITIONS WITH ENHANCED EFFICACY AND REDUCED METABOLIC SIDE EFFECTS AND TOXICITY FOR TREATMENT OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIO

The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azab

PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS

The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azab

Novel polymorphs of azabicyclohexane

The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.

NOVEL POLYMORPHS OF AZABICYCLOHEXANE

The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3, 4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.

Method of treating depression using azabicyclohexanes

The present invention concerns certain novel substituted 3-azabicyclo[3.1.0]hexanes and a method of treating depression and stress in a warm-blooded animal, comprising the administration of substituted 3-azabicyclo[3.1.0]hexanes.

Azabicyclohexanes

Substituted 3-azabicyclo[3.1.0]hexanes, acid addition salts, method of use and method of preparation are described. The compounds have anxiolytic and analgesic activity.