86215-36-3

Basic information

• Product Name: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL
• Synonyms: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride;DOV216303 HCl
• CAS NO: 86215-36-3
• Molecular Formula: C₁₁H₁₁Cl₂N*ClH
• Molecular Weight: 264.58
• Product Categories: pharmacetical
• Mol File: 86215-36-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 324.4°C at 760 mmHg
• Flash Point: 150°C
• Appearance: white to beige/
• Vapor Pressure: 0.000246mmHg at 25°C
• Storage Temp.: ?20°C
• Solubility: DMSO: ≥10mg/mL
• CAS DataBase Reference: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL(86215-36-3)
• EPA Substance Registry System: 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL(86215-36-3)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 86215-36-3(Hazardous Substances Data)

Usage

General Description

The chemical 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride (HCl) is a compound with potential pharmacological properties. It belongs to the class of bicyclic compounds and contains a phenyl group with two chlorine atoms. 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL may have applications in the field of medicinal chemistry and drug development, potentially targeting specific receptors or enzymes in the body. Further research and studies are needed to fully understand the potential uses and effects of this chemical.

InChI:InChI=1/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H

Upstream product

• 67644-29-5 1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane 
• 6725-44-6 methyl 2-(3,4-dichlorophenyl)acetate 
• 344245-65-4 1-(3,4-dichlorophenyl)-1,2-cyclopropanedicarboxylic acid 
• 163339-71-7 α-bromo-3,4-dichlorophenylacetic acid methyl ester 
• 877397-17-6 1-(3,4-dichlorophenyl)-1,2-cyclopropane-dicarboxylic acid dimethyl ester 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 66504-44-7 (±)-1-(3,4 dichlorophenyl)-3-azabicyclo[3.1.0]-hexane-2,4-dione 

Downstream Products

• 410074-74-7 Amitifadine hydrochloride 
• 410074-74-7 hydrochloride salt of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane 
• 410074-74-7 DOV 21,947 

Relevant articles and documents

USE OF AMITIFADINE, (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN METHODS AND COMPOSITIONS WITH ENHANCED EFFICACY AND REDUCED METABOLIC SIDE EFFECTS AND TOXICITY FOR TREATMENT OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIO

The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azab

Novel polymorphs of azabicyclohexane

The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.

Method of treating depression using azabicyclohexanes

The present invention concerns certain novel substituted 3-azabicyclo[3.1.0]hexanes and a method of treating depression and stress in a warm-blooded animal, comprising the administration of substituted 3-azabicyclo[3.1.0]hexanes.