344296-29-3

Basic information

• Product Name: Benzene, 1-bromo-2-(1,1-dimethylethoxy)-
• CAS NO: 344296-29-3
• Molecular Formula: C10H13BrO
• Molecular Weight: 229.117
• Mol File: 344296-29-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-2-(1,1-dimethylethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-2-(1,1-dimethylethoxy)-(344296-29-3)
• EPA Substance Registry System: Benzene, 1-bromo-2-(1,1-dimethylethoxy)-(344296-29-3)

Safety Data

• Hazardous Substances Data: 344296-29-3(Hazardous Substances Data)

Usage

General Description

Benzene, 1-bromo-2-(1,1-dimethylethoxy)- is a chemical compound with the molecular formula C10H15BrO. It is a bromo derivative of benzene with a 1,1-dimethylethoxy group attached to the 2-position. Benzene, 1-bromo-2-(1,1-dimethylethoxy)- is mainly used as an intermediate in organic synthesis and can be utilized in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the manufacturing of specialty chemicals and in research laboratories for various chemical reactions. Additionally, it has potential applications in the field of medicine and materials science due to its unique chemical properties. However, it is important to handle this compound with care, as it is considered to be harmful if swallowed, inhaled, or in contact with the skin.

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 115-11-7 isobutene 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 6337-33-3 2,2-dimethyl-2,3-dihydro-1-benzofuran 
• 25666-51-7 2-trifluoroacetylphenol 
• 1384516-75-9 C₂₇H₃₁N₂O₂⁽¹⁺⁾*Cl^(1-) 
• 1384516-78-2 C₃₀H₂₇N₄O₆⁽¹⁺⁾*Cl^(1-) 
• 1384516-77-1 C₃₁H₃₀N₃O₄⁽¹⁺⁾*Cl^(1-) 
• 1384516-76-0 C₂₃H₂₃N₂O₂⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

A Noncoordinating Acid-Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols

A mild and nonreversible tert-butylation of alcohols and phenols can be achieved in high yields using the noncoordinating acid-base catalyst [bis(trifluoromethane)sulfonimide and 2,6-lutidine] with a tert-butylation reagent, tert-butyl 2,2,2-trichloroacetimidate. This method allows the use of substrates containing acid sensitive groups such as ketal, Boc, and boronate esters.

Highly activatable and environment-insensitive optical highlighters for selective spatiotemporal imaging of target proteins

Optical highlighters are photoactivatable fluorescent molecules that exhibit pronounced changes in their spectral properties in response to irradiation with light of a specific wavelength and intensity. Here, we present a novel design strategy for a new class of caged BODIPY (4,4-difluoro-4-bora-3a, 4a-diaza-s-indacene) fluorophores, based on the use of photoremovable protecting groups (PRPGs) with high reduction potentials that serve as both a photosensitive unit and a fluorescence quencher via photoinduced electron transfer (PeT). 2,6-Dinitrobenzyl (DNB)-caged BODIPY was efficiently photoactivated, with activation ratios exceeding 600-fold in aqueous solutions. We then combined this photoactivatable fluorophore with a SNAP (mutant of O 6-alkylguanine DNA alkyltransferase) ligand to obtain a small-molecule-based optical highlighter for visualization of protein dynamics, using the well-established SNAP tag technology. As proof of concept, we demonstrate spatiotemporal imaging of the fusion protein of epidermal growth factor receptor (EGFR) with SNAP tag in living cells. We also demonstrate highlighting of cells of interest in live zebrafish embryos, using the fusion protein of histone 2A with SNAP tag.

High-yielding palladium-catalyzed intramolecular alkane arylation: Reaction development and mechanistic studies

Palladium-catalyzed alkane arylation reactions with aryl halides are described for the preparation of 2,2-dialkyl-dihydrobenzofuran substrates. These reactions occur in excellent yield and very high selectivity for the formation of one sole product arising from a reaction at nearby methyl groups. Mechanistic and computational studies point to the involvement of a concerted, inner-sphere palladation-deprotonation pathway that is enabled by the presence of three-center agostic interactions at the transition state. This mechanism accurately predicts the experimentally observed kinetic isotope effect as well as the site selectivity and should be useful in the design of new reactions and catalysts. Copyright