344346-05-0Relevant academic research and scientific papers
Total synthesis of greensporone C
Tadpetch, Kwanruthai,Jeanmard, Laksamee,Rukachaisirikul, Vatcharin
, p. 3453 - 3456 (2017)
The first total synthesis of greensporone C, a cytotoxic 14-membered resorcylic acid lactone, has been accomplished via a longest linear sequence of 16 steps in 3.3% overall yield. The key features of the synthesis include Mitsunobu esterification and ring-closing metathesis to construct the macrocycle and establish the (E)-olefin geometry, respectively. Our synthesis also confirmed the absolute stereochemistry of the natural product.
Synthesis and structure determination of iso-cladospolide B
Franck, Xavier,Vaz Araujo, Maria E.,Jullian, Jean-Christophe,Hocquemiller, Reynald,Figadère, Bruno
, p. 2801 - 2803 (2007/10/03)
iso-Cladospolide B 1 was previously characterized from the fungal isolate I96S215 obtained from a marine sponge collected in Indonesia. However, neither the relative nor the absolute configurations were reported. We describe in this letter a synthetic pathway which allowed us to prepare 1 and attribute the absolute configurations of the three stereogenic centers.
