344357-30-8

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 202846-63-7 (3S,4S)-4-(2-benzyloxyethyl)-3-hydroxy-4-methyl-γ-butyrolactone 
• 73840-71-8 diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate 
• 344357-29-5 (2S,3R)-5-benzyloxy-3-ethoxycarbonyl-2-hydroxy-3-methylpentanoic acid 
• 54555-84-9 benzyl iodoethyl ether 
• 202846-62-6 (2R,3S)-2-(2-Benzyloxy-ethyl)-3-hydroxy-2-methyl-succinic acid diethyl ester 

Downstream Products

• 165170-94-5 (5S,9S)-9-methyl-2-phenyl-9-vinyl-1,7-dioxaspiro[4.4]non-2-ene-4,6-dione 
• 344357-31-9 (3S,4S)-3-methoxymethyloxy-4-methyl-4-[2-(2-nitrophenyl)seleno]-γ-butyrolactone 
• 344357-19-3 (S)-3-[1-Hydroxy-2-(2-phenyl-[1,3]dioxolan-2-yl)-ethyl]-3-methoxymethoxy-4-methyl-4-vinyl-dihydro-furan-2-one 
• 344357-25-1 (3R,4R)-3-[3',3'-(ethylenedioxy)-3'-phenylpropanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-20-6 (3S,4R)-3-[3',3'-(ethylenedioxy)-3'-phenylpropanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-32-0 (S)-3-[(3R,4S)-1-Hydroxy-3-(4-methoxy-benzyloxy)-4-methyl-hexyl]-3-methoxymethoxy-4-methyl-4-vinyl-dihydro-furan-2-one 
• 344357-26-2 (3R,4R,3'R,4'S)-3-[3'-(4-methoxybenzyloxy)-4'-methylhexanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 
• 344357-21-7 (3S,4R,3'R,4'S)-3-[3'-(4-methoxybenzyloxy)-4'-methylhexanoyl]-3-methoxymethyloxy-4-methyl-4-vinyl-γ-butyrolactone 

Relevant academic research and scientific papers

Synthesis and absolute configuration of (+)-hyperolactone B

The synthesis of (+)-hyperolactone B 2, isolated from Hypericum chinense L., was accomplished from (S)-malic acid. The synthesis unambiguously established the absolute stereochemistry of hyperolactone B.

Synthesis of Hyperolactones A and C

Hyperolactones A (1) and C (3) have been synthesized starting from (S)-malic acid by a straightforward route. The unique spirolactone skeleton was efficiently constructed by one-pot reaction as a key step. The absolute stereochemistry of hyperolactones was unambiguously established by this synthesis.