344396-17-4

Basic information

• Product Name: Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester
• Synonyms: 4-Isopropyl-3,5-dimethoxy-benzoic acid methyl ester;methyl 4-isopropyl-3,5-dimethoxybenzoate;methyl 3,5-dimethoxy-4-isopropyl-benzoate
• CAS NO: 344396-17-4
• Molecular Formula: C13H18O4
• Molecular Weight: 238.284
• Mol File: 344396-17-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 108 °C
• Boiling Point: 338.3±42.0 °C(Predicted)
• Density: 1.057±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester(344396-17-4)
• EPA Substance Registry System: Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester(344396-17-4)

Safety Data

• Hazardous Substances Data: 344396-17-4(Hazardous Substances Data)

Usage

Description

Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester, also known as methyl 3,5-dimethoxy-4-isopropylbenzoate, is an organic compound belonging to the class of benzoic acid esters. It is characterized by its pleasant odor and unique chemical properties, making it a versatile substance for various applications.

Uses

Used in Perfumery and Fragrance Industry:
Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester is used as a fragrance ingredient for its pleasant odor, contributing to the creation of various perfumes and fragrances.
Used in Essential Oils:
This chemical compound can be found in essential oils, where its aromatic properties enhance the overall scent profile.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester is utilized in applications requiring the inhibition of microbial growth, ensuring the preservation of products.
Used in Pharmaceutical Synthesis:
Benzoic acid, 3,5-dimethoxy-4-(1-methylethyl)-, methyl ester is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications.
Used in Food Industry as a Flavoring Agent:
In the food industry, this compound is employed as a flavoring agent to enhance the taste and aroma of various food products, providing a pleasant sensory experience for consumers.

Upstream product

• 80041-89-0 isopropylboronic acid 
• 26050-64-6 methyl 4-bromo-3,5-dimethoxybenzoate 
• 75-29-6 isopropyl chloride 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 74-88-4 methyl iodide 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 16534-12-6 3,5-dihydroxy-4-bromobenzoic acid 
• 67-56-1 methanol 
• 866821-31-0 methyl 3,5-dimethoxy-4-(prop-1-en-2-yl)benzoate 

Downstream Products

• 1006706-87-1 C₁₃H₁₇BrO₄ 
• 344396-18-5 4-isopropyl-3,5-dimethoxy-benzyl alcohol 
• 344396-19-6 3,5-dimethoxy-4-(1-methylethyl)benzaldehyde 
• 141509-20-8 (E)-1,3-dimethoxy-2-(1-methylethyl)-5-(2-phenylethenyl)benzene 
• 1622988-14-0 (Z)-3,5-dihydroxy-4-isopropylstilbene 
• 115781-08-3 3,5-dihydroxy-4-isopropyl stilbene 
• 866821-34-3 5-[1-(4-isopropyl-3,5-dimethoxyphenyl)-5-methyl-5-hexenylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 866821-30-9 (+/-)-5-[1-(4-isopropyl-3,5-dimethoxyphenyl)-1,5-dimethyl-5-hexenyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 866821-42-3 (+/-)-5-[1-(4-isopropyl-3,5-dimethoxyphenyl)-1,4-dimethyl-4-pentenyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 866821-41-2 (+/-)-5-[1-(4-isopropyl-3,5-dimethoxyphenyl)-1,5-dimethyl-4-hexenyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 866821-38-7 2-(4-isopropyl-3,5-dimethoxy-benzoyl)-5-methyl-hex-5-enoic acid methyl ester 

Relevant articles and documents

Industrial preparation method of 3,5-dimethoxy-4-alkylbenzyl alcohol

The invention discloses an industrial preparation method of 3,5-dimethoxy-4-alkylbenzyl alcohol, belonging to the technical field of organic synthesis. According to the method, isopropyl chloride or isopropyl alcohol p-toluenesulfonate is selected, and isopropyl alcohol p-toluenesulfonate is directly subjected to Friedel-Crafts alkylation under the action of triethylamine hydrochloride ionic liquid serving as both a solvent and a catalyst; after the above reaction is finished, an organic solvent, such as methyl tert-butyl ether, is used for direct extraction and liquid separation, and the ionic liquid can be used repeatedly; sodium borohydride is directly used for reducing acyl imidazole obtained by subjecting isopropyl ester obtained in the previous stepto exchanging with imidazole in an aqueous tetrahydrofuran solution mildly (under the condition of 0-30 DEG C and without adding a catalyst); and after reduction is completed, a reduction product is directly poured into strong alkali solution with a concentration of 1-6 mol/L for quenching, and an organic phase is separated, so the 3,5-dimethoxy-4-alkylbenzyl alcohol is obtained safely and environmentally. The method is convenient and safe to operate, greatly reduces the problem of environmental pollution, and is suitable for industrial production.

Efficient synthesis of sterically hindered arenes bearing acyclic secondary alkyl groups by suzuki-miyaura cross-couplings

Bulky P,P-O ligands were designed to inhibit isomerization and reduction side reactions during the cross coupling between sterically hindered aryl halides and alkylboronic acids. Suzuki-Miyaura cross-couplings between di-ortho-substituted aryl bromides and acyclic secondary alkylboronic acids have been achieved with high yields. The method has also enabled the preparation of ortho-alkoxy di-ortho-substituted arenes bearing isopropyl groups in excellent yields. The utility of the synthetic method has been demonstrated in a late-stage modification of estrone and in the application to a new synthetic route toward gossypol. No side reaction: The shown bulky P,P-O ligands (right) successfully inhibit isomerization and reduction side reactions of the cross-coupling of sterically hindered substrates such as di-ortho-substituted aryl bromides with acyclic secondary alkylboronic acids. The method also allows the preparation of ortho-alkoxy di-ortho-substituted isopropyl arenes in excellent yields.

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1–R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.