34452-39-6Relevant academic research and scientific papers
Diboration of 3-substituted propargylic alcohols using a bimetallic catalyst system: access to (Z)-allyl, vinyldiboronates
Peck, Cheryl L.,Nekvinda, Jan,Santos, Webster L.
supporting information, p. 10313 - 10316 (2020/09/16)
The diboration of substituted propargylic alcohols has been achieved using a bimetallic Pd/Cu catalyst system. Thein situformation of a pentrafluoroboronic acid intermediate sufficiently activates the C-O bond towards dual catalysis affording (Z)-allyl, vinyldiboronates stereoselectively.
Catalytic Access to Functionalized Allylic gem-Difluorides via Fluorinative Meyer–Schuster-Like Rearrangement
An, Rui,Li, Huimin,Liao, Lihao,Wu, Jin-Ji,Xu, Yang,Zhao, Xiaodan
supporting information, p. 11010 - 11019 (2020/05/18)
An unprecedented approach for efficient synthesis of functionalized allylic gem-difluorides via catalytic fluorinative Meyer–Schuster-like rearrangement is disclosed. This transformation proceeded with readily accessible propargylic fluorides, and low-cost B–F reagents and electrophilic reagents by sulfide catalysis. A series of iodinated, brominated, and trifluoromethylthiolated allylic gem-difluorides that were difficult to access by other methods were facilely produced with a wide range of functional groups. Importantly, the obtained iodinated products could be incorporated into different drugs and natural products, and could be expediently converted into many other valuable gem-difluoroalkyl molecules as well. Mechanistic studies revealed that this reaction went through a regioselective fluorination of alkynes followed by a formal 1,3-fluorine migration under the assistance of the B–F reagents to give the desired products.
A stereoselective synthesis of the dihydroxyethylene dipeptide isostere, A-82768
Krysan, Damian J.,Haight, Anthony R.,Menzia, Jerome A.,Welch, Noel
, p. 6163 - 6172 (2007/10/02)
A stereocontrolled synthesis of the dihydroxyethylene dipeptide isostere, A-82768, 1 via an erythro-selective addition of a Grignard reagent to a cis α,β-epoxy aldehyde is described. The resulting erythro-epoxy alcohol was converted to the desired 3-amino
Nor-statine and nor-cyclostatine polypeptides
-
, (2008/06/13)
Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
