129765-71-5Relevant academic research and scientific papers
Copper(i)-catalysed stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes with bis(pinacolato)diboron
Pang, Yadong,Kojima, Ryoto,Ito, Hajime
supporting information, p. 6187 - 6190 (2018/09/10)
A stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes to prepare (Z)-1-bromo-1-alkenylboronate esters using copper(i) catalysts was developed. The debromoborylation of various aliphatic 1,1-dibromo-1-alkenes in the presence of a copper(i) catalyst and bis(pinacolato)diboron proceeded smoothly to produce (Z)-1-bromo-1-alkenylboronate esters in good yields with only Z geometry.
Practical Synthesis of Polysubstituted Haloimidazoles from 1,1-Dibromoalkenes and Amidines
Li, Yibiao,Cheng, Liang,Shao, Yan,Jiang, Shaohua,Cai, Jialing,Qing, Ning
supporting information, p. 4325 - 4329 (2015/07/27)
The copper-catalyzed cycloamination reaction of 1,1-dibromoalkenes with amidines affords a diverse set of polysubstituted haloimidazole derivatives. By using this strategy, high regio- and chemoselectivity has been achieved, using 4,7-diphenyl-1,10-phenanthroline as ligand without the addition of expensive catalysts to provide moderate to good yields. The copper-catalyzed cycloamination reaction of 1,1-dibromoalkenes with amidines affords a diverse set of polysubstituted haloimidazole derivatives. Moderate to good yields with high regio- and chemoselectivities were achieved by using 4,7-diphenyl-1,10-phenanthroline as ligand without the addition of expensive catalyst.
A stereoselective synthesis of the dihydroxyethylene dipeptide isostere, A-82768
Krysan, Damian J.,Haight, Anthony R.,Menzia, Jerome A.,Welch, Noel
, p. 6163 - 6172 (2007/10/02)
A stereocontrolled synthesis of the dihydroxyethylene dipeptide isostere, A-82768, 1 via an erythro-selective addition of a Grignard reagent to a cis α,β-epoxy aldehyde is described. The resulting erythro-epoxy alcohol was converted to the desired 3-amino
RENIN-INHIBITING AMINODIOL DERIVATIVES
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, (2008/06/13)
The invention relates to compounds of the formula I STR1 in which A denotes a radical of the formula II STR2 in which E denotes a CH. sub.2 group or an NR 9 radical,G denotes a radical from the group comprising S, SO, SO 2, O, CO, CS or a direct bon
Use of lithium (trimethylstannyl)(cyano)cuprate for the conversion of alkyl 2-alkynoates into alkyl (Z)- and (E)-3-trimethylstannyl-2-alkenoates
Piers, Edward,Wong, Timothy,Ellis, Keith A.
, p. 2058 - 2064 (2007/10/02)
Reaction of functionalized alkyl 2-alkynoates (e.g., 13-19) with lithium (trimethylstannyl)(cyano)cuprate (3) under two sets of carefully defined experimental conditions provides, efficiently and stereoselectively, either alkyl (Z)- or (E)-3-trimethylstan
