344563-86-6

Upstream product

• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 98-88-4 benzoyl chloride 
• 614-34-6 p-cresyl benzoate 
• 106-44-5 p-cresol 

Downstream Products

• 133363-94-7 Benzoic acid [1-(3-benzoyl-2-hydroxy-5-methyl-phenyl)-1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 133363-95-8 Acetic acid [1-(3-benzoyl-2-hydroxy-5-methyl-phenyl)-1-phenyl-meth-(Z)-ylidene]-hydrazide 
• 133364-00-8 (2,6-Dibenzoyl-4-methyl-phenyl)-phenyl-methanone 
• 77347-19-4 2,6-dibenzoyl-4-methylphenol 

Relevant academic research and scientific papers

Synthesis and crystallographic analysis of benzophenone derivatives-The potential anti-inflammatory agents

Fries rearrangement of substituted phenyl benzoates 1a-j to substituted hydroxy benzophenones 2a-j was achieved in excellent yield. Further benzoylation of 2a-j to benzoyloxy benzophenones 4a-n, a benzophenone analogue was achieved in good yield. All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compounds 4c, 4e, 4g, 4h and 4k with chloro and methyl substituents at para position showed more potent activity than the standard drugs at all doses tested.

Synthesis and crystal structure of 2-benzoyl-4-methyl phenyl benzoate

The crystal structure of the title compound, C21H 16O3, has been determined. The compound crystallizes in triclinic space group PI with cell parameters a = 9.2240(9) A, b = 9.8050(8) A, c = 10.1610(11) A, α = 94.749(6)°, β = 112.544(4)°, γ = 102.145(6)° and Z = 2. The structure exhibits both intra and intermolecular interactions of the type C-H...O. The intermolecular interaction between the molecules form centrosymmetric dimers.

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes

Benzoylation of (hydroxy phenyl) phenyl methanone 2a-g to benzoyl phenyl benzoates 4a-g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 [E.C. 3.1.1.4] and hyaluronidase [E.C. 3.2.1.35] enzyme inhibitory activity in snake venom as source and their structure-activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated.

Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents

The newly synthesized compounds dibenzoyl phenols 4a-f using microwave irradiation were screened for their anti-inflammatory activity and compared with standard drugs. Benzoylation of hydroxybenzophenones 1a-f affords substituted benzoyl phenyl benzoates

A novel and facile synthesis of 1,2,3-triacylbenzenes

3,4,5-Triacyltoluenes 7 were prepared in high yield by a novel oxidative cleavage reaction of 2,6-diacylcresol monohydrazone 6 with lead tetraacetate.