344592-45-6Relevant academic research and scientific papers
ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
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Paragraph 0195; 0196; 0197, (2017/07/14)
Compounds represented by Formula (I) and (II) and salts thereof are described herein. The compounds or salts of Formula (I) and (II) may be used to treat senescence-associated diseases and disorders.
Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity
Reichenberg, Armin,Wiesner, Jochen,Weidemeyer, Claus,Dreiseidler, Erhard,Sanderbrand, Silke,Altincicek, Boran,Beck, Ewald,Schlitzer, Martin,Jomaa, Hassan
, p. 833 - 835 (2007/10/03)
The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to ip drug administration.
