686718-73-0Relevant academic research and scientific papers
Stereoselective synthesis of 5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl) ethyl]-dihydrofuran-2-one
Li, Bryan,Buzon, Richard A.,Chiu, Charles K.-F.,Colgan, Stephen T.,Jorgensen, Matthew L.,Kasthurikrishnan, Narasim
, p. 6887 - 6890 (2004)
Phthalic anhydride as thiolate scavenger effectively preserved the enantiopurity of α-aminoketone, thus affording the convenient synthesis of the titled lactone. A short, efficient, and highly diastereoselective synthesis of 5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl)ethyl]-dihydrofuran-2-one (1) is described. Use of phthalic anhydride as thiolate scavenger effectively preserves the chiral integrity of the α-aminoketone 4 product obtained from the reaction of organozincate 3 with thioester 2.
