34469-09-5

Basic information

• Product Name: [R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol
• Synonyms: (1R)-1-Phenyl-2-(dimethylamino)ethanol;(R)-1-Phenyl-2-(dimethylamino)ethanol;(R)-α-[(Dimethylamino)methyl]benzenemethanol;(αR)-α-(Dimethylaminomethyl)benzyl alcohol;[R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol;Ubine
• CAS NO: 34469-09-5
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 0
• Mol File: 34469-09-5.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: [R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol(34469-09-5)
• EPA Substance Registry System: [R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol(34469-09-5)

Safety Data

• Hazardous Substances Data: 34469-09-5(Hazardous Substances Data)

Usage

General Description

[R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol is a chiral compound with the chemical formula C16H21NO. It is commonly used as a pharmaceutical intermediate or reagent in organic synthesis. The compound consists of a benzyl alcohol group with a dimethylamino methyl substituent attached to the alpha carbon. [R,(-)]-α-[(Dimethylamino)methyl]benzyl alcohol has a wide range of applications, including its use as a reagent in the synthesis of various pharmaceutical drugs and other organic compounds. Because of its chiral nature, it can exist as different stereoisomers, with the R-enantiomer being the more commonly used form in organic synthesis.

Upstream product

• 6853-14-1 2-dimethylamino-1-phenylethanol 
• 34469-10-8 (S)-2-(dimethylamino)-2-oxo-1-phenylethyl acetate 
• 50-00-0 formaldehyd 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 3319-03-7 2-dimethylamino-1-phenyl-ethanone 
• 64-18-6 formic acid 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 61185-97-5 2-dimethylamino-1-phenyl-ethanone; hydrochloride 
• 611-71-2 (R)-Mandelic Acid 
• 73908-23-3 (R)-2-bromo-1-phenylethanol 
• 532-27-4 1-chloroacetophenone 
• 56751-12-3 2-chloro-1-phenylethanol 
• 70-11-1 α-bromoacetophenone 
• 2202-65-5 (R)-2-(dimethylamino)-2-phenylethanol 

Downstream Products

• 127677-23-0 Propionic acid (S)-2-dimethylamino-1-phenyl-ethyl ester 
• 1375799-72-6 (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(1-(trifluoromethyl)cyclobutanecarboxamido)-4,6 dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 
• 1375799-71-5 (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(1-(trifluoromethyl)cyclopropanecarboxamido)-4,6 dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 
• 1375799-69-1 (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate- 
• 1041012-54-7 (S)-2-(dimethylamino)-1-phenylethyl 6,6 dimethyl-3-(tetrahydro-2H-pyran-2-carboxamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate- 
• 1041012-52-5 (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(tetrahydrofuran-2-carboxamido)-4,6-dihydropyrrolo[3,4-c]-pyrazole-5(1H)-carboxylate 
• 1041012-42-3 (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-pivalamido-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 
• 1041012-33-2 (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(picolinamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 
• 1041012-29-6 (S)-2-(dimethylamino)-1-phenylethyl 3-(2,4-difluorobenzamido)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 

Relevant articles and documents

An iron variant of the Noyori hydrogenation catalyst for the asymmetric transfer hydrogenation of ketones

We report the design of a new iron catalyst for the asymmetric transfer hydrogenation of ketones. This type of iron catalyst combines the structural characteristics of the Noyori hydrogenation catalyst (an axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl fragment and the metal-ligand bifunctional motif) and an ene(amido) group that can activate the iron center. After activation by 8 equivalents of potassiumtert-butoxide, (SA,RP,SS)-7aand (SA,RP,SS)-7bare active but nonenantioselective catalysts for the transfer hydrogenation of acetophenone and α,β-unsaturated aldehydes at room temperature in isopropanol. A maximum turnover number of 14480 was observed for (SA,RP,SS)-7ain the reduction of acetophenone. The right combination of the stereochemistry of the axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl group and the carbon-centered chiral amine-imine moiety in (SA,RP,RR)-7b′afforded an enantioselective catalyst for the preparation of chiral alcohols with moderate to good yields and a broad functional group tolerance.

waylen apperception HIV reverse transcriptase inhibitors in accordance with the law of the process for the asymmetric synthesis of one-pot synthesis (by machine translation)

The invention relates to a novel one pot method asymmetric synthesis process of a (S)-6-chlorine-4-cylopropyl ethylnen-4-trifluoromethyl-1,4-dihydro-2H-1,3-benzoxazine-2-ketone (Efavirenz) compound, the compound can be used as an reverse transcriptase inhibitor for human immunodeficiency virus (HIV). The invention also relates to a novel aminoalcohol ligand used for the process.

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