344779-94-8Relevant articles and documents
Design, modeling and synthesis of functionalized paromamine analogs
Hanessian, Stephen,Tremblay, Martin,Kornienko, Alexander,Moitessier, Nicolas
, p. 3255 - 3265 (2007/10/03)
Based on the published NMR structure of the antibiotic paromomycin complexed with the A-site of Escherichia coli 16S ribosomal RNA, a set of C-5 functionalized analogs of paromamine was designed and synthesized, incorporating cyclic and acyclic appendages and terminating with one or more ammonium groups.