3449-44-3Relevant academic research and scientific papers
Reactions of alkyl 2-benzylidene-2-polyfluoroacylacetates with N,N-dinucleophiles
Pryadeina,Burgart,Kodess,Saloutin,Chupakhin
, p. 1261 - 1266 (2004)
Alkyl 2-benzylidene-2-polyfluoroacylacetates react with urea and thiourea to yield 5-ethoxycarbonyl-4-fluoroalkyl-4-hydroxy-6-phenylhexahydropyrimidin-2- ones and -2-thiones and with guanidine sulfate to form 2-amino-5-ethoxycarbonyl- 4-fluoroalkyl-6-phenyl-1,6-dihydropyrimidines and 3,6-diethoxycarbonyl-2,7- difluoroalkyl-4,5-diphenyl-4,5-dihydro-1H-pyrido[1,2-a]pyrimidines, and they react with phenylhydrazine to afford 4-alkoxycarbonyl-3-fluoroalkyl-3-hydroxy-1, 5-diphenylpyrazolidines. Hydrazine hydrate catalyzes the formation of 3,5-diethoxycarbonyl-2,6-difluoroalkyl-2,6-dihydroxy-4-phenyltetrahydropyrans. When treated with anhydrous hydrazine and o-phenylenediamine, these esters cleave to form the products of condensation of fluoroacyl ester and benzaldehyde with diamines.
Synthesis of 2,6-bis(fluoroalkyl)-2,6-dihydroxytetrahydro-2H-pyran-3,5- dicarboxylates from aldehydes and fluorinated β-oxo esters in the presence of ionic liquid-K2CO3 as catalytic system
Zlotin,Kryshtal',Zhdankina,Ignatenko,Burgart,Saloutin,Chupakhin
experimental part, p. 468 - 473 (2010/07/06)
An efficient procedure has been developed for the synthesis of 4-substituted 2,6-bis(fluoroalkyl)-2,6-dihydroxytetrahydro-2H-pyran-3,5- dicarboxylates by reactions of aldehydes with fluorine-containing β-oxo esters in heterogeneous catalytic system 1-buty
