34495-86-8Relevant articles and documents
Catalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines
Duan, Wentao,Lian, Qi,Wang, Songping,Wei, Wentao,Zhou, Jingwei
supporting information, p. 3261 - 3267 (2021/05/21)
Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on our well-designed C-C single bond cleavage mechanism, we discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2as a benign oxidant under very mild conditions. The utility of our methodology was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, our methodology is noteworthy, not only in that it does not require any catalysts, but also in that it provides valuable possibilities for the scalable functionalization of clinical drugs and natural products.
Method for exciting C-C bond fracture acylation and application
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Paragraph 0034-0042; 0214-0222, (2021/07/21)
The invention provides a method for exciting C-C bond breakage acylation and application; the method comprises the following steps: mixing a compound with a structural formula shown in the specification with an organic solvent, and reacting in oxygen and
EFFECT OF THE STRUCTURE OF N-SUBSTITUTED 1,3-OXAAZACYCLOPENTANES ON THEIR REACTIVITY IN FREE-RADICAL ISOMERIZATION
Lapshova, A. A.,Zorin, V. V.,Zlotskii, S. S.,Karakhanov, R. A.,Rakhmankulov, D. L.
, p. 325 - 330 (2007/10/02)
During the thermal decomposition of tert-butyl peroxide (120 - 150 deg C) in a medium of N-substituted 1,3-oxaazacyclopentanes the latter change into the N,N-disubstituted amides of carboxylic acids by a mechanism of an unbranched chain reaction with quadratic termination at the rearranged radicals.The effect of the nature and the position of the substituents on the reactivity of 1,3-oxaazacyclopentanes in the free-radical isomerization reaction was investigated.The kinetic data and activation parameters characterizing the reactivity of 1,3-oxaazacyclopentanes were determined.