344957-25-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyanobenzylamine is used as a key intermediate in the preparation of benzazepine derivatives, which are histamine H3 antagonists. These antagonists have potential applications in the treatment of various disorders, such as cognitive impairment, attention deficit hyperactivity disorder (ADHD), and Alzheimer's disease.
Used in Agrochemical Industry:
2-Cyanobenzylamine can also be used as a building block in the synthesis of agrochemicals, such as herbicides and insecticides, due to its versatile chemical properties and reactivity.

InChI:InChI=1/C8H8N2/c9-5-7-3-1-2-4-8(7)6-10/h1-4H,5,9H2

Upstream product

• 7647-01-0 hydrogenchloride 
• 157117-83-4 2-<(2-Cyan-phenyl)methyl>-2H-isoindol-1,3-dion 
• 40508-03-0 2-(azidomethyl)benzonitrile 
• 91-15-6 phthalonitrile 
• 626-17-5 benzene-1,3-dicarbonitrile 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 612-13-5 2-cyanobenzyl chloride 

Downstream Products

• 439118-51-1 (2-cyanobenzyl)carbamic acid tert-butyl ester 
• 40508-03-0 2-(azidomethyl)benzonitrile 
• 91-15-6 phthalonitrile 
• 850649-61-5 alogliptin 
• 1638544-64-5 Alogliptin benzoate 
• 439116-13-9 tert-butyl N-[[2-(aminomethyl)phenyl]methyl]carbamate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING m-XYLYLENE DIAMINE

PROBLEM TO BE SOLVED: To provide a method for producing m-xylylene diamine that makes it possible to efficiently produce m-xylylene diamine by reducing the formation of by-products even when a reaction temperature is lowered in a hydrogenation reaction step. SOLUTION: In the presence of a catalyst with palladium carried on carbon and in the absence of ammonia and an amine compound (excluding a reaction product), 1,3-dicyanobenzene and hydrogen are reacted at 0°C or higher and 50°C or lower, and hydrogen is added to the 1,3-dicyanobenzene, producing m-xylylene diamine. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H- tetrazol-5-amine P2X7 antagonists

Synthesis and biological evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the

An efficient hydrogenation of dinitrile to aminonitrile in supercritical carbon dioxide

The highly selective hydrogenation of adiponitrile proceeds effectively in supercritical carbon dioxide (scCO2) to produce 6-aminocapronitrile with excellent selectivity of 100% over rhodium/alumina (Rh/Al2O 3) and without any additive, which is impossible in classical organic solvents. The presence of CO2 can be beneficial or mandatory for the exclusive formation of the aminonitrile as it can act as a solvent to enhance the activity and also as temporary protecting agent to increase the selectivity. These results successfully show the general concept of using scCO2 as a protective medium for the selectivity control of dinitrile to aminonitrile reactions. Recycling of the catalyst and further extension of this method to other dinitriles were also investigated.

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

Thrombin inhibitors incorporating o-aminoalkylbenzylamides in the P1 position were designed, synthesized and found to have enhanced potency and selectivity in several different structural classes. X-ray crystallographic analysis of compound 24 bound in the α-thrombin-hirugen complex provides an explanation for these unanticipated results.