2-cyanobenzylamine

Base Information

• Chemical Name: 2-cyanobenzylamine
• CAS No.: 344957-25-1
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Hs Code.: 2926909090
• Mol file: 344957-25-1.mol

Synonyms:2-Aminomethyl-benzonitrile;o-cyanobenzylamine;2-(aminomethyl)benzenecarbonitrile;2-(3-CHLORO-4-FLUOROPHENOXY)ETHYLAMINEHYDROCHLORIDE;2-Cyan-benzylamin;2-CYANOBENZYLAMINE;

Chemical Property of 2-cyanobenzylamine

Chemical Property:

• Vapor Pressure: 0.016mmHg at 25°C
• Boiling Point: 255.819oC at 760 mmHg
• PKA: 8.01±0.10(Predicted)
• Flash Point: 108.516oC
• PSA: 49.81000
• Density: 1.101g/cm3
• LogP: 1.71728
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-(Aminomethyl)benzonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Cyanobenzylamine is used in the preparation of benzazepine derivatives as histamine H3 antagonists.

Technology Process of 2-cyanobenzylamine

There total 9 articles about 2-cyanobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.6%

phthalonitrile (91-15-6) → 2-(aminomethyl)benzonitrile (344957-25-1)

Guidance literature:

With carbon dioxide; Rh/Al₂O₃; hydrogen; at 80 ℃; for 6h; chemoselective reaction;

DOI:10.1002/adsc.201000514

Reference yield: 24.0%

benzene-1,3-dicarbonitrile (626-17-5) → 1,3-di(aminomethyl)benzene (1477-55-0) + 2-(aminomethyl)benzonitrile (344957-25-1) + C14H17N3

Guidance literature:

With palladium/alumina; In methanol; at 29 - 34 ℃; for 2h; under 7500.75 Torr; Reagent/catalyst; Temperature;

Reference yield:

2-<(2-Cyan-phenyl)methyl>-2H-isoindol-1,3-dion (157117-83-4) → 2-(aminomethyl)benzonitrile (344957-25-1) + benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5)

Guidance literature:

upstream raw materials:

2-cyanobenzyl chloride

hydrogenchloride

2-<(2-Cyan-phenyl)methyl>-2H-isoindol-1,3-dion

2-(azidomethyl)benzonitrile

Downstream raw materials:

(2-cyanobenzyl)carbamic acid tert-butyl ester

tert-butyl N-[[2-(aminomethyl)phenyl]methyl]carbamate

2-(azidomethyl)benzonitrile

Alogliptin benzoate