345-91-5

Usage

Uses

Used in Pharmaceutical Industry:
4-FLUORO-4'-METHYLBENZHYDROL is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for versatile chemical reactions, facilitating the creation of complex molecules with potential medicinal properties.
Used in Organic Chemistry Research:
In the field of organic chemistry, 4-FLUORO-4'-METHYLBENZHYDROL serves as a valuable reagent in chemical reactions, enabling the synthesis of a wide range of organic compounds. Its presence in reactions can influence the outcome, providing researchers with a useful tool for exploring new chemical pathways and synthesizing novel molecules.
Used in Production of Complex Molecules:
4-FLUORO-4'-METHYLBENZHYDROL is utilized as a building block for the production of more complex molecules, particularly in the synthesis of advanced organic compounds. Its structural features make it an ideal candidate for incorporation into larger molecular frameworks, expanding the scope of organic chemistry and contributing to the discovery of new materials and compounds.
Used in Medicinal and Pharmaceutical Research:
Although further studies are required to fully understand its properties and potential applications, 4-FLUORO-4'-METHYLBENZHYDROL may have promising uses in medicinal and pharmaceutical research. Its unique structure and reactivity could lead to the development of new therapeutic agents, offering new avenues for the treatment of various diseases and conditions.

Upstream product

• 530-46-1 4-fluoro-4'-methylbenzophenone 
• 5720-05-8 4-methylphenylboronic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 403-43-0 4-fluorobenzoyl chloride 
• 108-88-3 toluene 

Downstream Products

• 2353-66-4 2-(4-fluoro-4'-methyl-benzhydryl)-2-nitro-indan-1,3-dione 
• 39769-57-8 C₁₄H₁₂F⁽¹⁺⁾ 
• 64583-38-6 C₁₄H₁₂ClF 
• 64583-41-1 C₁₄H₁₂BrF 
• 530-46-1 4-fluoro-4'-methylbenzophenone 

Relevant academic research and scientific papers

Electronic Effect-Guided Rational Design of Candida antarctica Lipase B for Kinetic Resolution Towards Diarylmethanols

Herein, we developed an electronic effect-guided rational design strategy to enhance the enantioselectivity of Candida antarctica lipase B (CALB) mutants towards bulky pyridyl(phenyl)methanols. Compared to W104A mutant previously reported with reversed S-stereoselectivity toward sec-alcohols, three mutants (W104C, W104S and W104T) displayed significant improvement of S-enantioselectivity in the kinetic resolution (KR) of various phenyl pyridyl methyl acetates due to the increased electronic effects between pyridyl and polar residues. The electronic effects were also observed when mutating other residues surrounding the stereospecificity pocket of CALB, such as T42A, S47A, A281S or A281C, and can be used to manipulate the stereoselectivity. A series of bulky pyridyl(phenyl) methanols, including S-(4-chlorophenyl)(pyridin-2-yl) methanol (S-CPMA), the intermediate of bepotastine, were obtained in good yields and ee values. (Figure presented.).

The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones.

Arylation of carbonyl compounds catalyzed by rhodium and iridium 1,3-R 2-tetrahydropyrimidin-2-ylidenes: Structure-reactivity correlations

Six different well-defined rhodium and iridium N-heterocyclic carbene complexes, i.e., RhCl-(1,3-dimesityltetrahydropyrimidin-2-ylidene)(COD) (1), RhBr(1,3-dimesityltetrahydropyrimidin-2-ylidene)-(COD) (2), RhCl[1,3-di(2- propyl)tetrahydropyrimidin-2-ylidene](COD) (3), IrCl(1,3- dimesityltetrahydropyrimidin-2-ylidene)(COD) (4), Rh(CF3COO) (1,3-dimesityltetrahydropyrimidin-2-ylidene)(COD) (5), and IrBr[1,3-di(2-propyl) tetrahydropyrimidin-2-ylidene](COD) (6) (COD = 1,5-cyclooctadiene, mesityl = 2,4,6-trimethylphenyl) have been used as catalysts for the arylation of aldehydes and α,β-unsaturated ketones using different arylboronic acids. Compounds 1-4 and 6 were prepared by reaction of [RhCl(COD)]2 and [IrCl(COD)]2, respectively, with a base and the corresponding 1,3-R2-tetrahydropyrimidinium salt. Compound 5 was prepared by reaction of 1.0 equivalents of CF3COOAg with 1. The use of an excess of CF3COOAg resulted in the replacement of Rh(I) by Ag(I) and yielded Ag(1,3-dimesityltetrahydropyrimidin-2-ylidene)+Rh 2(CF3COO)3(COD)- (8). Compounds 4 and 8 were characterized by X-ray analysis. The activity of the rhodium complexes increased in the order 5 > 3 > 1 > 2, indicating the necessity of strongly electron-withdrawing groups at the metal centers, thus increasing their nucleophilicity. In due consequence, the softer iridium complexes 4 and 6 exhibited significantly reduced catalytic activity albeit with enhanced selectivity. The syntheses of the metal complexes as well as a detailed study on their reactivity in the arylation of carbonyl compounds using equimolar amounts of arylboronic acid and carbonyl compound in the presence of 0.08-1 mol % catalyst are presented.