3451-51-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-1,3,4-oxadiazole is used as a chemical intermediate for the synthesis of pharmaceutically active compounds due to its potential to contribute to substances with medicinal or therapeutic effects.
Used in Research and Development:
2-Methyl-1,3,4-oxadiazole serves as a subject of study in chemical research, particularly in exploring its properties, potential applications, and the development of its derivatives for various uses, including medicinal purposes.

InChI:InChI=1/C3H4N2O/c1-3-5-4-2-6-3/h2H,1H3

Upstream product

• 51410-11-8 1-tetrazol-2-ylethanone 
• 1068-57-1 acetic acid hydrazide 
• 149-73-5 trimethyl orthoformate 
• 13148-73-7 N'-acetyl-formohydrazonic acid N'-acetyl-hydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 108-24-7 acetic anhydride 
• 624-84-0 formic acid hydrazide 
• 13148-69-1 N'-acetyl-formohydrazonic acid ethyl ester 

Downstream Products

• 4661-63-6 N-phenyl-(4-phenylpiperidine)-1-carboxamide 
• 1004305-59-2 7-phenoxy-1-(5-methyl-1,3,4-oxadiazol-2-yl)-heptan-1-ol 
• 1004305-70-7 1-(3'-benzyloxy-1,1'-biphenyl-3-yl)-1-(5-methyl-1,3 ,4-oxadiazol-2-yl)-methanol 
• 756819-68-8 4-cyclohexyl-3-methyl-4H-1,2,4-triazole 
• 1380492-48-7 4-(2,6-diisopropylphenyl)-3-methyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

Development of orally active nonpeptidic inhibitors of human neutrophil elastase

5-Amino-2-phenylpyrimidin-6-ones, some of their desamino derivatives, and miscellaneous derivatives were synthesized and biologically evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. These compounds contained an α-keto-1,3,4-oxadiazole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE). Among those tested, compounds 11a-c,e,i-l(F), 11d,e,k(H), 21d,e,k(F), and 21d,e(H) showed a good oral profile. RS-Mixture 3(H) was selected for clinical evaluation based on its oral potency, duration of action, enzyme selectivity, safety profile, and ease of synthesis. Structure -activity relationships (SARs) are discussed.

PHOTOCHEMISTRY OF N-ACYLAZOLES. VI). PHOTOREACTIVITIES OF 1-ACYL-1,2,4-TRIAZOLES AND OF 2-ACYLTETRAZOLES

Contrary to the findings in the photolysis of N-acylimidazoles (2) irradiation of 1-acyl-1,2,4-triazoles afforded no photo-Fries product, but instead products formed via the corresponding acyl radicals and aldehydes.Photolysis of 2-acyltetrazoles gave in part the same products as those obtained from the irradiation of the corresponding acyl-triazoles as well as 2-alkyl-1,3,4-oxadiazoles.N-Acyltetrazoles didn't give any photo-Fries product neither.