345231-54-1

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 33342-73-3 α-(N-methyl-N-benzylamino)-3,4-dimethoxyacetophenone 

Downstream Products

• 5653-66-7 1-(3,4-dimethoxyphenyl)-2-(methylamino)ethan-1-ol 
• 25836-15-1 2-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 345228-39-9 2-methyl-4-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Dopamine Agonist Properties of N-Alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines

A series of homologous N-alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines was synthesized and examined for a dopamine-like ability to dilate the renal artery.The N-methyl derivative was equipotent to the 3',4'-dihydroxy derivative of the antidepressant agent nomifensine, indicating that the 8-amino group of the latter is not essential for dopamine-like activity.The N-ethyl homologue was reduced in potency when compared to the N-methyl, and the N-n-propyl, surprisingly, was essentially devoid of activity.This was unexpected in view of the fact that in all series of dopamine-like agents reported to date, N-alkylation, when one of the alkyls was an n-propyl group, either allowed retention or enhancement of potency.