345307-80-4

Upstream product

• 81581-43-3 3-Methoxy-1-(4-methoxy-phenyl)-8-oxo-5,6,7,8-tetrahydro-isoquinoline-4-carbonitrile 
• 7402-39-3 2-(4-methoxybenzoyl)cyclohexanone 
• 81581-41-1 3-Methoxy-1-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-isoquinoline-4-carbonitrile 
• 81581-40-0 3-hydroxy-1-(4-methoxyphenyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 

Downstream Products

• 81581-48-8 3-Methoxy-1-(4-methoxy-phenyl)-1,2-dihydro-isoquinoline-4-carbonitrile 
• 81581-50-2 3-Methoxy-1-(4-methoxy-phenyl)-isoquinoline-4-carbonitrile 
• 81581-45-5 3-Methoxy-1-(4-methoxy-phenyl)-5,6-dihydro-isoquinoline-4-carbonitrile 

Relevant academic research and scientific papers

Amide-Catalysed Isomerisation of 5,6-Dihydroisoquinolines: a Novel Synthesis of 1,2-Dihydroisoquinolines

Knoevenagel condensation of 2-acylcyclohexanones or 2-ethoxycarbonylcyclohexanone with either cyanoacetamide or malononitrile followed by silver salt alkylation gave the 5,6,7,8-tetrahydroisoquinolines (3a-i).Chromic acid oxidation of the 5,6,7,8-tetrahyd