7402-39-3Relevant academic research and scientific papers
Iridium-catalyzed reaction of enones with alcohols affording 1,3-diketones
Obora, Yasushi,Nakamura, Kazuhiro,Hatanaka, Shintaro
supporting information; experimental part, p. 6720 - 6722 (2012/07/17)
An iridium-catalyzed coupling reaction of alcohols with enones has been successfully developed providing access to 1,3-diketones with high selectivity in good yields. This reaction provides an atom-economical route to 1,3-diketones from readily available
Regiochemistry of the condensation of 2-aroyl-cyclohexanones and 2-cyanoacetamide: 13C-labeling studies and semiempirical MO calculations
Van Linden, Oscar P. J.,Wijtmans, Maikel,Roumen, Luc,Rotteveel, Lonneke,Leurs, Rob,De Esch, Iwan. J. P.
, p. 7355 - 7363 (2012/11/07)
Hydroxy-aryl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles represent interesting chemical scaffolds, but synthetic access to these compounds is limited. The reaction of 2-aroyl-cyclohexanones with 2-cyanoacetamide and base in ethanol has been reported to
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase
Van Linden, Oscar P.J.,Farenc, Carine,Zoutman, Willem H.,Hameetman, Liesbeth,Wijtmans, Maikel,Leurs, Rob,Tensen, Cornelis P.,Siegal, Gregg,De Esch, Iwan J.P.
supporting information; experimental part, p. 493 - 500 (2012/03/11)
The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially
1,3-Diketones from acid chlorides and ketones: A rapid and general one-pot synthesis of pyrazoles
Heller, Stephen T.,Natarajan, Swaminathan R.
, p. 2675 - 2678 (2007/10/03)
1,3-Diketones were synthesized directly from ketones and acid chlorides and were then converted in situ into pyrazoles by the addition of hydrazine. This method is extremely fast, general, and chemoselective, allowing for the synthesis of previously inaccessible pyrazoles and synthetically demanding pyrazole-containing fused rings.
Synthesis of Isomeric Series of Aryltetrahydrobenzisoxazoles and Arylcyclopentisoxazoles
Fos, Empar,Borras, Liset,Gasull, Maria,Mauleon, David,Carganico Germano
, p. 203 - 208 (2007/10/02)
Four series of potential PAF-antagonists in which the isoxazole nucleus is condensed with a polyhydrogenated five- or six-carbon ring were prepared.The synthesis of the compounds 3-aryl-4,5,6,7-tetrahydrobenzisoxazoles 1, 3-arylcyclopentisoxazole 2,
