345579-51-3Relevant academic research and scientific papers
BENZYLOXYPROPYLAMINE DERIVATIVE
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Page/Page column 22, (2010/11/24)
Disclosed is a novel benzyloxypropylamine derivative having an excellent tachykinin receptor antagonistic effect. This compound shows a good transfer into the blood and a long blood half-life in the blood kinetic test using a guinea pig orally administered with the compound and is stable in an animal plasma. The compound also shows a high transfer to the central nervous system when it is orally administered to a guinea pig at a certain dose. Accordingly, the benzyloxypropylamine derivative is quite useful as a novel anti-tachykinin agent.
Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions
Shue, Ho-Jane,Chen, Xiao,Schwerdt, John H.,Paliwal, Sunil,Blythin, David J.,Lin, Ling,Gu, Danlin,Wang, Cheng,Reichard, Gregory A.,Wang, Hongwu,Piwinski, John J.,Duffy, Ruth A.,Lachowicz, Jean E.,Coffin, Vicki L.,Nomeir, Amin A.,Morgan, Cynthia A.,Varty, Geoffrey B.,Shih, Neng-Yang
, p. 1065 - 1069 (2007/10/03)
A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve p
