403-31-6

Basic information

• Product Name: 4'-FLUORO-2-HYDROXYACETOPHENONE
• Synonyms: RARECHEM AL BD 0490;1-(4-FLUOROPHENYL)-2-HYDROXY-1-ETHANONE;1-(4-FLUOROPHENYL)-2-HYDROXYETHANONE;2-HYDROXY-1-(4-FLUOROPHENYL)ETHANONE;2-HYDROXY-4-FLUOROACETOPHENONE;1-(4-Fluorophenyl)-2-hydroxyethan-1-one 95%;1-(4-Fluorophenyl)-2-hydroxy-1-ethanone95%;1-(4-Fluorophenyl)-2-hydroxyethan-1-one
• CAS NO: 403-31-6
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• Mol File: 403-31-6.mol
• Article Data: 47

Chemical Properties

• Melting Point: 31 °C
• Boiling Point: 260.5 °C at 760 mmHg
• Flash Point: 111.3 °C
• Appearance: /
• Density: 1.256 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-FLUORO-2-HYDROXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO-2-HYDROXYACETOPHENONE(403-31-6)
• EPA Substance Registry System: 4'-FLUORO-2-HYDROXYACETOPHENONE(403-31-6)

Safety Data

• Hazard Codes: Xi,F
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-31-6(Hazardous Substances Data)

Usage

General Description

4'-Fluoro-2-hydroxyacetophenone is a chemical compound with the molecular formula C8H7FO2. It is a white solid with a faint, sweet odor, and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 4'-FLUORO-2-HYDROXYACETOPHENONE is used in various industries, including pharmaceuticals, agrochemicals, and fragrances. It is also used as a precursor in the production of other chemicals and has potential applications in medicinal chemistry, due to its pharmacological properties. The chemical structure of 4'-fluoro-2-hydroxyacetophenone contains a fluorine atom and a hydroxyl group, which give it unique properties and reactivity, making it useful for a wide range of applications.

Upstream product

• 141-53-7 sodium formate 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 124-41-4 sodium methylate 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 459-57-4 4-fluorobenzaldehyde 
• 298-12-4 Glyoxilic acid 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 67-56-1 methanol 
• 58518-77-7 ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane 
• 140373-17-7 α-hydroxymethyl-4-fluorobenzylamine 
• 357952-79-5 1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 18511-62-1 4-fluorostyrene oxide 
• 17951-22-3 1-(4-fluorophenyl)ethane-1,2-diol 
• 350-40-3 2-(4-fluorophenyl)-1-propene 

Downstream Products

• 123365-30-0 1-(4-Fluoro-phenyl)-2-methoxymethoxy-ethanone 
• 1025506-04-0 4-(4-fluorophenyl)-5H-[1,2,3]oxathiazole 2,2-dioxide 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 1215085-77-0 1-(4-fluorophenyl)-2-(2-propenyloxy)ethanone 
• 1266549-11-4 (4S)-3-[(Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)hex-4-enoyl]-4-phenyl-ox azolidin-2-one 
• 1266549-14-7 [4-[(Z,1S,2R)-6-tert-butyldimethylsilyloxy-1-(4-fluoroanilino)-5-(4-fluorophenyl)-2-[ (4S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl]hex-4-enyl]phenyl] benzoate 
• 1266548-94-0 (3R,4S)-3-[(Z)-4-acetoxy-3-(4-fluorophenyl)-but-2-enyl]-4-(4-benzoyloxyphenyl)-1-( 4-fluorophenyl)azetidin-2-one 
• 1266548-97-3 ethyl (Z)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl) but-2-enoate 
• 1266548-98-4 ethyl (E)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl) but-2-enoate 
• 1266548-99-5 (Z)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl)but-2-en-1-ol 
• 1266549-01-2 tert-butyl-[(Z)-4-chloro-2-(4-fluorophenyl)but-2-enoxy]-dimethyl-silane 
• 1266549-03-4 dimethyl 2-[(Z)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl)but-2-enyl]propanedioate 
• 1266549-05-6 (Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)-2-methoxycarbonyl-hex-4-enoic acid 
• 1266549-07-8 methyl (Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)hex-4-enoate 

Relevant articles and documents

Aerobic Direct Dioxygenation of Terminal/Internal Alkynes to α-Hydroxyketones by an Fe Porphyrin Catalyst

We herein report a new synthetic method for the preparation of α-hydroxyketones by the dioxygenation of alkynes. The reaction proceeds at room temperature under the action of Fe porphyrin and pinacolborane under air as a green oxidant to produce α-hydroxyketones. The mild reaction conditions allow chemoselective oxidation with functional group tolerance. Terminal alkynes in addition to internal alkynes are applicable, affording unsymmetrical α-hydroxyketones that are difficult to obtain by any reported dioxygenation of unsaturated C?C bonds.

Enantioselective Cascade Biocatalysis for Deracemization of Racemic β-Amino Alcohols to Enantiopure (S)-β-Amino Alcohols by Employing Cyclohexylamine Oxidase and ω-Transaminase

Optically active β-amino alcohols are very useful chiral intermediates frequently used in the preparation of pharmaceutically active substances. Here, a novel cyclohexylamine oxidase (ArCHAO) was identified from the genome sequence of Arthrobacter sp. TYUT010-15 with the R-stereoselective deamination activity of β-amino alcohol. ArCHAO was cloned and successfully expressed in E. coli BL21, purified and characterized. Substrate-specific analysis revealed that ArCHAO has high activity (4.15 to 6.34 U mg?1 protein) and excellent enantioselectivity toward the tested β-amino alcohols. By using purified ArCHAO, a wide range of racemic β-amino alcohols were resolved, (S)-β-amino alcohols were obtained in >99 % ee. Deracemization of racemic β-amino alcohols was conducted by ArCHAO-catalyzed enantioselective deamination and transaminase-catalyzed enantioselective amination to afford (S)-β-amino alcohols in excellent conversion (78–94 %) and enantiomeric excess (>99 %). Preparative-scale deracemization was carried out with 50 mM (6.859 g L?1) racemic 2-amino-2-phenylethanol, (S)-2-amino-2-phenylethanol was obtained in 75 % isolated yield and >99 % ee.

Palladium-Catalyzed (3+3) Annulation of Allenylethylene Carbonates with Nitrile Oxides

In this paper, we designed and synthesized a new type of cyclic carbonates, allenylethylene carbonates (AECs). With AECs as reactive precursors, we developed palladium-catalyzed (3+3) annulation of AECs with nitrile oxides. Various AECs worked well in this reaction under mild reaction conditions. A variety of 5,6-dihydro-1,4,2-dioxazine derivatives with allenyl quaternary stereocenters can be accessed in a facile manner in high yields (≤98%).