34577-38-3

Upstream product

• 6245-96-1 α-naphthylmethyl phenyl ether 
• 67-63-0 isopropyl alcohol 
• 2876-78-0 methyl 1-naphthylacetate 
• 75-16-1 methylmagnesium bromide 
• 86-87-3 naphth-1-yl acetic acid 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 217480-50-7 4-chloromethyl-2,2-dimethyl-1,2-dihydrobenzo[f]isoquinoline 
• 1427307-52-5 2,2-dimethyl-4-(2-furyl)-1,2-dihydrobenzo[f]iso-quinoline 

Relevant academic research and scientific papers

(ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula 1, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases

Cyclic nitrones

The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.

CLEVEAGE RATES FOR RADIOLYSIS-PRODUCED RADICAL ANIONS OF NAPHTHYLMETHYL PHENYL ETHERS AND NAPHTHYL BENZYL ETHERS

Cleveage reactions of α- and β-naphthylmethyl phenyl ethers and of α- and β-naphthyl benzyl ethers were studied by pulse radiolysis.Transient spectra indicate that reactions occur via electron capture followed by cleavage of the resultant radical anions to give arylmethyl radicals and aryloxide ions.Product studies of extensively irradiated samples are consistent with this scheme and show patterns which are informative for radiation studies in general.The reactions were studied in several solvents.The behavior of transient spectra obtained in acetonitrile for these ethers shows clearly that radical anions of the naphthylmethyl ethers cleave more rapidly than do the radical anions of the naphthyl benzyl ethers.

A Facile Cyclialkylation Approach to the Synthesis of 1,1-Dimethyl- and 1,1,2-Trimethylacenaphthenes

A facile approach to the synthesis of 1,1-dimethylacenaphthene (4) and 1,1,2-trimethylacenaphthene (7) has been made through Friedel-Crafts cyclialkylation of intermediate carbinols.Reactions catalyzed by AlCl3/CH3NO2 produce compound 4 from the isomeric 2-methyl-1-(α-naphthyl)-2-propanol (3) and 2-methyl-1-(α-naphthyl)-1-propanol (12) and compound 7 from the isomeric 2-methyl-2-(α-naphthyl)-2-butanol (6) and 2-methyl-2-(α-naphthyl)-1-butanol (13).On the other hand, reactions catalyzed by H2SO4 (85 percent) produce 2-methyl-1-(α-naphthyl)propene (8) from carbinols 3 and 12, 2-methyl-3-(α-naphthyl)-2-butene (9) from carbinol 6, and 7 from carbinol 13.Mechanistic evaluation shows that cyclidehydration using AlCl3/CH3NO2 as catalyst does not involve alkene intermediates.The hitherto unreported thermal rearrangement of acenaphthene 4 to alkene 8 has been discovered.