345932-52-7

Upstream product

• 64-18-6 formic acid 
• 88783-79-3 (2,4-Dinitrophenyl)(4-biphenylyl)amine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 92-67-1 4-phenylalanine 
• 47162-05-0 N¹-Biphenyl-4-yl-benzene-1,2,4-triamine 

Downstream Products

• 85346-51-6 1-([1,1'-biphenyl]-4-yl)-1H-benzo[d]imidazole 
• 1217467-93-0 1-(biphen-4-yl)-5-(4-methyl-1-phthalazinyl)aminobenzimidazole hydrochloride 
• 85346-49-2 (1-Biphenyl-4-yl-1H-benzoimidazol-2-yl)-methanol 

Relevant academic research and scientific papers

SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION

Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof. R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2' is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofuryhnethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring lactone; R4 is independently hydrogen, (C1-C6)alkyl, a 2- or 4-R5-substituted aromatic ring selected from a 4-R5-phenyl or a 2-R5-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R5, R5', R6, R6', R7, R7' are each independently hydrogen, (C1-C6)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.

FREE-RADICAL HYDROXYMETHYLATION OF BENZIMIDAZOLE

Several benzimidazole derivatives were subjected to free-radical hydroxymethylation.Benzimidazole displays lower activity than quinoline in the first stage of the transformation, viz., in the addition of the hydroxymethyl radical.The yields of hydroxymeth